RLS No RLS P value Female 14/30 5/19 0.41 Age (years, mean ± SD) 64.0 ± 13.1 56.2 ± 12.4 0.87 Prevalence of Diabetes 15/30 7/19 0.61 Peritoneal Dialysis 5/6 1/6 0.24 Duration of Dialysis (years, mean ± SD) 3.1 ± 2.3 2.4 ± 1.3 0.18 AC of PCC (mean ± SD) 1.17 ± 0.65 n = 30 0.87 ± 0.39 n = 19 0.007

Table 1: Demographic Characteristics and Activation Coefficient (AC) for Propionyl- CoA Carboxylase (PCC) for Participants in Study 1 with and Without Restless Legs Syndrome (RLS).