| |
Tacrolimus
group (n=41) |
Cyclosporine
group (n=20) |
P value |
| Age (year) |
35.1 ± 8.0 |
44.8 ± 11.7 |
0.001 |
| Gender (male/female) |
32/9 |
14/6 |
0.351 |
| Source of allograft (living/deceased) |
24/17 |
14/6 |
0.281 |
| Body mass index (kg/m2) |
26.5 ± 4.4 |
24.9 ± 3.7 |
0.147 |
| Duration after transplantation (mo) |
12 (1-105) |
98.5 ± (5-252) |
0.001 |
| Use of ACEI or ARB |
12 (29.3%) |
7 (35.0%) |
0.432 |
| Use of vitamin D |
11 (26.8%) |
9 (45.0%) |
0.130 |
| Use of steroid |
40 (97.6%) |
20 (100%) |
0.672 |
| Use of mycophenolate |
36 (87.8%) |
9 (45.0%) |
0.001 |
| Use of azathioprine |
4 (9.8%) |
8 (40.0%) |
0.008 |
| Systolic blood pressure (mmHg) |
131 ± 18 |
124 ± 13 |
0.129 |
| Diastolic blood pressure (mmHg) |
90 ± 14 |
84 ± 14 |
0.142 |
| Serum magnesium (mEq/L) |
1.44 ± 0.5 |
1.52 ± 0.2 |
0.002 |
| Presence of hypomagnesemia |
24 (58.%) |
2 (10%) |
0.001 |
| Serum sodium (mEq/L) |
138 ± 3 |
137 ± 5 |
0.309 |
| Serum potassium (mEq/L) |
4.2 ± 0.3 |
4.3 ± 0.4 |
0.179 |
| Serum calcium (mg/dL) |
9.6 ± 0.5 |
9.4 ± 0.6 |
0.164 |
| Serum phosphorus (mg/dL) |
3.0 ± 1.0 |
3.3 ± 0.6 |
0.239 |
| Serum uric acid (mg/dL) |
6.5 ± 1.4 |
7.1 ± 1.6 |
0.321 |
| Serum glucose (mg/dL) |
102.8 ± 19.6 |
98.8 ± 15.7 |
0.429 |
| Serum albumin (g/dL) |
4.0 ± 0.5 |
3.8 ± 0.4 |
0.041 |
| Hemoglobin (g/dL) |
13.9 ± 2.0 |
13.5 ± 1.9 |
0.440 |
| Intact parathormon (pg/mL) |
75 (4.8-532) |
76 (12-834) |
0.951 |
| Fractional excretion of sodium (%) |
1.3 (0.5-4.5) |
1.6 (0.5-5) |
0.499 |
| Fractional excretion of magnesium (%) |
6.9 ± 3.8 |
6.5 ± 3.3 |
0.675 |
| Creatinine clearance (mL/min) |
71.7 ± 27.9 |
60.4 ± 25.2 |
0.130 |
| Amount of proteinuria (mg/d) |
54 (0-1130) |
157 (0-1880) |
0.186 |
| Amount of 24-h urine volume (mL) |
3415 ± 1120 |
3519 ± 1224 |
0.749 |
ACEI: angiotensin converting enzyme inhibitor, ARB: angiotensin II receptor
blocker