eNOS-/- db/db

eNOS-/- high-dose STZ

eNOS-/- low-dose STZ

eNOS-/- low-dose STZ, HF

eNOS-/- Akita

eNOS+/- Akita

 

Ref.16

Ref.15

Ref.40

Ref.14

Ref.47

Ref.47

u-albumin

­

­

­

­

­

­

GFR

¯

not determined

¯

¯

¯

­

GBM thickening

+

+

+

+

+

+

mesangial expansion

+

+

+

+

+

+

mesangiolysis

+

+

+

-

+

+

nodular sclerosis

+

+

+

+

+

+

tubulointerstitial fibrosis

-

+

-

+

-

-

arteriolar hyalinosis

+

+

not determined

-

-

-

Table 1: Features of diabetic nephropathy in mice with decreased eNOS expression.