Transplant characteristic
(reference level) |
Hazard
ratio |
95 % CI |
p |
Donor gender (male)
Female |
1.73 |
1.05 – 2.84 |
0.02 |
Recipient gender (male)
Female |
0.99 |
0.95 – 1.05 |
0.98 |
Recipient age at transplantation 18 – 34
(35 – 54), years 55 – 64
> 64 |
1.19
2.16
3.53 |
0.34 – 4.23
1.19 – 3.9
1.39 – 8.94 |
0.79
0.01
0.01 |
Donor age 18 – 34
(55 – 64), years 35 – 54
> 64 |
0.88
1.04
3.64 |
0.77 – 1.00
0.84 – 1.29
1.4 – 8.76 |
0.10
0.49
0.01 |
Renal disease (unspecified)
Glomerulonephritis
Interstitial nephritis
Polycystic kidney disease |
1.37
1.04
0.99 |
0.36 – 5.23
0.99 – 1.09
0.86 – 1.15 |
0.64
0.11
0.89 |
Pretransplant dialysis time
(3 – 10) months 11 – 54
> 54 |
1.38
1.16 |
0.55 – 3.46
0.81 – 1.67 |
0.50
0.55 |
Pretransplant dialysis type (peritoneal dialysis)
Hemodialysis
|
0.45 |
0.12 – 1.79 |
0.26 |
Donor source (living donor)
Deceased donor
|
3.76 |
1.02 – 13.9 |
0.05 |
Treatment AR (no treat AR)
Cs
ATG |
1.96
1.88 |
1.33 – 2.89
1.35 – 2.61 |
0.01
0.02 |
CMV proph/treat BD (no proph/treat)
yes proph/treat |
2.16 |
1.19 – 3.90 |
0.01 |
Immunosuppressive therapy (CyA,MMF,Cs)
Fk,MMF,Cs
|
3.53 |
1.39 – 8.94 |
0.01 |
The BKV-infection incidence was significantly higher in recipients of female
donor, in older recipients, in recipients of older donor, in recipients with a history
of CMV prophylaxis/treatment, in recipients of deceased donor, in recipients
with a history of episode of AR, in recipients with an immunosuppressive therapy
based on Fk and MMF association. Fk = tacrolimus, MMF = mycophenolate
mofetil, Cs = steroid, CyA = cyclosporine, ATG = antithymocyte globulins,
CMV = cytomegalovirus, AR = acute rejection, BD = before diagnosis. See text
for details. |