Transplant characteristic
(reference level)

Hazard
ratio

95 % CI

p

Donor gender (male)

Female

 

1.73

 

1.05 – 2.84

 

0.02

Recipient gender (male)
   
Female

 

0.99

 

0.95 – 1.05

 

0.98

Recipient age at transplantation       18 – 34
   (35 – 54), years                             55 – 64
                                                         >  64

1.19
2.16
3.53

0.34 – 4.23
1.19 – 3.9
1.39 – 8.94

0.79
0.01
0.01

Donor age                                         18 – 34
   (55 – 64), years                              35 – 54
                                                           >  64

0.88
1.04
3.64

0.77 – 1.00
0.84 – 1.29
1.4   – 8.76

0.10
0.49
0.01

Renal disease (unspecified)
  Glomerulonephritis
  Interstitial nephritis
  Polycystic kidney disease

 

1.37
1.04
0.99

 

0.36 – 5.23
0.99 – 1.09
0.86 – 1.15

 

0.64
0.11
0.89

Pretransplant dialysis time
  (3 – 10) months                                 11 – 54
                                                            >  54

 

1.38
1.16

 

0.55 – 3.46
0.81 – 1.67

 

0.50
0.55


Pretransplant dialysis type (peritoneal dialysis)
   Hemodialysis

 

0.45

 

0.12 – 1.79

 

0.26


Donor source (living donor)
   Deceased donor

 

3.76

 

1.02 – 13.9

 

0.05

Treatment AR (no treat AR)
                            
Cs
ATG

 

1.96
1.88

 

1.33 – 2.89
1.35 – 2.61

 

0.01
0.02

CMV proph/treat BD (no proph/treat)
    yes proph/treat

2.16

1.19 – 3.90

0.01


Immunosuppressive therapy (CyA,MMF,Cs)
Fk,MMF,Cs

 

3.53

 

1.39 – 8.94

 

0.01

The BKV-infection incidence was significantly higher in recipients of female donor, in older recipients, in recipients of older donor, in recipients with a history of CMV prophylaxis/treatment, in recipients of deceased donor, in recipients with a history of episode of AR, in recipients with an immunosuppressive therapy based on Fk and MMF association. Fk = tacrolimus, MMF = mycophenolate mofetil, Cs = steroid, CyA = cyclosporine, ATG = antithymocyte globulins, CMV = cytomegalovirus, AR = acute rejection, BD = before diagnosis. See text for details.
Table 2: Risk factors between two groups for BKV-viremia. Multivariate Cox regression analyses with time to BKV-viremia as the dependent variable.