Cirrhosis with ascites

Serum creatinine >133 μmol/l (1.5 mg/dl)

No improvement of serum creatinine (decrease to a level of ≤133 μmol/l) after at least 2 days with diuretic withdrawal and volume expansion with albumin. The recommended dose of albumin is 1 g/kg of body weight per day up to a maximum of 100 g/day
Absence of shock

No current or recent treatment with nephrotoxic drugs
Absence of parenchymal kidney disease as indicated by proteinuria >500 mg/day, microhematuria (>50 red blood cells per high power field) and/or abnormal renal ultrasonography

Table 1: International Ascites Club (IAC) proposed diagnostic criteria for hepatorenal syndrome [13].