S.No CMR ID KO number Protein name Gene name E.C Number Metabolic pathways Subcellular localization Structure Drug prioritization
1 SP0105 K01752 L-serine dehydratase, iron-sulfur-dependent, alpha subunit sdhA 4.3.1.17 Glycine, serine, threonine cysteine and methionine metabolism Cytoplasmic membrane No No
2 SP0175 K00794 6,7-dimethyl-8-ribityllumazine synthase ribH 2.5.1.78 Riboflavin metabolism Cytoplasmic No Yes
3 SP0179 K03550 Holliday junction DNA helicase RuvA ruvA 3.6.4.12 Homologous recombination Cytoplasmic No No
4 SP0193 K07447 Putative Holliday junction resolvase ruvX 3.1.-.- No pathway Cytoplasmic No No
5 SP0369 K05366 Penicillin-binding protein 1A ponA 2.4.1.- 3.4.-.- Peptidoglycan biosynthesisa Extracellular Yes Yes
6 SP0387 K11618 DNA-binding response regulator rr03 - Two-component systema Cytoplasmic No Yes
7 SP0408 K03310 Sodium: alanine symporter family protein - - No pathway Membrane No No
8 SP0417 K00648 3-oxoacyl-(acyl-carrier-protein) synthase III fabH 2.3.1.180 Fatty acid biosynthesis Cytoplasmic No Yes
9 SP0424 K02372 (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase fabZ 4.2.1.- Fatty acid biosynthesis Cytoplasmic No Yes
10 SP0585 K00549 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase metE 2.1.1.14 Cysteine and methionine metabolism, Selenocompound metabolism Cytoplasmic No Yes
11 SP0611 K07462 Single-stranded-DNA-specific exonuclease RecJ recJ 3.1.-.- Base excision repair, mismatch repair, homologous recombination Cytoplasmic No No
12 SP0775 K02959 Ribosomal protein S16 rpsP - Ribosome Cytoplasmic No Yes
13 SP0851 K08591 Glycerol-3-phosphate acyltransferase plsY 2.3.1.15 Glycerolipid and glycerophospholipid metabolism Membrane No No
14 SP0878 K03466 DNA translocase ftsK - No pathway Membrane No No
15 SP0895 K02337 DNA polymerase III, alpha subunit dnaE 2.7.7.7 Purine metabolism, pyrimidine metabolism, DNA replication, Mismatch repair, Homologous recombination Cytoplasmic No No 
16 SP0936 K02341 DNA polymerase III, delta prime subunit holB 2.7.7.7 Purine metabolism, pyrimidine metabolism, DNA replication, Mismatch repair, Homologous recombination Cytoplasmic No Yes
17 SP0938 K07056 Tetrapyrrole methylase family protein rsmI 2.1.1.198 No pathway Cytoplasmic No No
18 SP0991 K01243 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase mtf 3.2.2.9 Cysteine and methionine metabolism Cytoplasmic Yes Yes  
19 SP1072 K02316 DNA primase dnaG 2.7.7.- DNA replication Cytoplasmic No No
20 SP1073 K03086 RNA polymerase sigma-70 factor rpoD - No pathway Cytoplasmic No Yes
21 SP1100 K00625 Phosphate acetyltransferase pta 2.3.1.8 Taurine and hypotaurine metabolism, Pyruvate metabolism, Propanoate metabolism, Methane metabolisma Cytoplasmic No Yes
22 SP1105 K02888 Ribosomal protein L21 rplU - Ribosome Cytoplasmic, Cytoplasmic Membrane, Cellwall, Extracellular No No
23 SP1113 K03530 DNA-binding protein HU hup - No pathway Cytoplasmic No No
24 SP1176 K08483 Phosphoenolpyruvate-protein phosphotransferase ptsI 2.7.3.9 Phosphotransferase systema Cytoplasmic No Yes
25 SP1285 K03501 Glucose-inhibited division protein B rsmG 2.1.1.170 No pathway Cytoplasmic No No
26 SP1412 K13292 Prolipoprotein diacylglyceryl transferase lgt 2.-.-.- No pathway Cytoplasmic membrane No No
27 SP1429 K08303 Peptidase, U32 family   3.4.-.- Epithelial cell signaling in Helicobacter pylori infection Cytoplasmic No No
28 SP1517 K03624 Transcription elongation factor greA - No pathway Cytoplasmic No No
29 SP1702 K03070 Preprotein translocase, SecA subunit secA1 - Bacterial secretion systema Cytoplasmic No Yes
30 SP1748 K07574 Conserved hypothetical protein   - No pathway Cytoplasmic No No
31 SP1777 K09457 Conserved hypothetical protein queF 1.7.1.13 No pathway Cytoplasmic No Yes
32 SP1910 K06878 Conserved hypothetical protein   - No pathway Cytoplasmic No No
33 SP2007 K02601 Transcription antitermination protein nusG - No pathway Cytoplasmic No No
34 SP2044 K00925 Acetate kinase ackA 2.7.2.1 Taurine and hypotaurine metabolism, Pyruvate metabolism, Propanoate metabolism, Methane metabolisma Cytoplasmic No No
35 SP2097 K00674 Putative 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase dapH 2.3.1.117 Lysine biosynthesis Cytoplasmic No Yes
36 SP2126 K01687 Dihydroxy-acid dehydratase ilvD 4.2.1.9 Valine, leucine and isoleucine biosynthesis, pantothenate and CoA biosynthesis Cytoplasmic No No
37 SP2203 K02314 Replicative DNA helicase dnaC 3.6.4.12 DNA replication Membrane No No
aRepresents targets from unique pathways of bacterial meningitis pathogens
CMR ID: Comprehensive Microbial Resource, KO ID: KEGG orthology, EC no: Enzyme Commission number.
Table 1: Putative drug targets of common bacterial meningitis.