| Drugs |
Target |
In vivo Model: Organ I/R Injury |
Reference |
| SA13353 |
TNF-α production via TRPV1 |
Rat: kidney |
[140] |
| Resiniferatoxin |
TNF-α production via TRPV1 |
Rat: kidney |
[141] |
| capsaicin |
TNF-α production via TRPV1 |
Rat: kidney |
[141] |
| FR167653 |
p38 MAPK |
Pig: kidney |
[144,145] |
| FR167653 |
p38 MAPK |
Rat: mouse, dog: liver |
[142, 146,147, 149, 177] |
| FR167653 |
p38 MAPK |
Rat: liver, lung |
[148] |
| FR167653 |
p38 MAPK |
Dog: intestine |
[143] |
| TNF-α shRNA |
TNF-α |
Mouse: liver |
[151] |
| TNF-α antisense oligonucleotides |
TNF-α |
Rat: liver |
[152] |
| Curcumin |
Unknown |
Rat: kidney |
[202] |
| TNFR1-IgG fusion protein via adenovirus gene transfer |
TNF-α |
Rat: lung |
[153] |
| rhTIMP-3 |
TACE/ADAM17 |
Rat: liver |
[58,59] |
| Recombinant TNF binding protein (rhTNF-BP1) |
TNF-α |
Rat: liver |
[156] |
| Eritoran |
Toll-like receptor 4 (TLR) |
Rat: kidney |
[158] |
| TNF-α |
N/A |
Mouse: liver |
[159] |
|
| Table 4: Experimental drugs using multiple mechanisms to target TNF-α and TNF-α -related factors in ischemia/reperfusion (I/R) injury. Abbreviations: TNF-α, tumor necrosis
factor-α; TRPV1, transient receptor potential vanilloid 1; MAPK, mitogen activated protein kinase; TACE/ADAM-17, TNF-α -converting enzyme/a disintegrin and metalloproteinase
domain 17; TLR, toll-like receptor; shRNA, small hairpin RNA; TNFR1, TNF-α receptor 1; rhTIMP-3, recombinant human tissue inhibitor metalloproteinase-3; rhTNF-BP1, recombinant human TNF-α binding protein-1; N/A, not applicable. |