Myelin Loss? Axon Loss? Microglia Activation? Peripheral Immune Response? Anti-CNS Immunity? Progressive Disease phenotype? References OL DEATH MODEL DTR Y/N Y/N Y N N Y [1,2] DT-a Y N Y N ? Y [3,4] iCP9 Y N Y N ? N [5] Cuprizone Y N Y N ? Y [6-10]

Table 1: A comparison of the development of pathologies and potential outcomes in each model is likely to shed light on both novel roles for oligodendrocytes in neurophysiology as well as in the pathogenesis of demyelinating diseases.