Figure 1: The role of endothelial cell (EC) caveolin-1 (Cav-1) in disease. Green indicates pathological processes promoted by a loss of EC Cav- 1 in rodent models of disease or in patients with pulmonary hypertension. Thus, approaches restoring or mimicking Cav-1 expression in ECs from patients with pulmonary hypertension might have therapeutic potential. Red represents pathological processes suppressed by a loss of endothelial Cav-1 in mouse models of disease. Thus, approaches suppressing Cav-1 expression or antagonizing Cav-1 function in ECs could potentially alleviate pathological processes such as atherosclerosis, or acute lung injury, as well as pathological angiogenesis associated with tumor growth and inflammatory bowel disease.