Figure 2: Epistatic effects on cancer traits in mice fed separate diets. Each example includes a bar diagram that shows the epistatic effects of two QTLs on the trait in each dietary group (* = P < 0.05). There also is a second line diagram that shows how epistasis in each group affects the relationship among the nine genotypic values (M = gene from M16i line, F = gene from FVB line) generated from the interaction of the two QTLs. Figure 2A illustrates epistatic effects of QTLs on chromosomes 11 and 17 on TOID in male mice that are significant in both dietary environments (differential effects). Figure 2B illustrates differential epistatic effects of QTLs on chromosomes 17 and 18 on MET in female mice.