Trait

Ch1

Ch2

Loc1

Loc2

LOD

aad

add

dad

ddd

LOD-C

LOC-H
         

MALES

            

TOID (6.173, 5.025)

TOID

1

2

23

97

5.77

*

*

  

*

1.00

0.76

TOID

1

3

23

44

6.16

  

*

    

.

1.38

TOID

1

9

16

38

5.77

*

*

  

*

0.91

0.78

TOID

1

17

24

25

5.29

    

*

*

3.70

0.00

TOID

2

4

42

72

5.27

  

*

  

*

5.89

2.90

TOID

2

16

36

26

5.11

*

*

*

*

0.03

2.92

TOID

4

11

66

55

5.79

*

*

*

*

3.57

2.55

TOID

8

11

31

3

5.79

      

*

1.09

5.32

TOID

8

12

53

31

5.42

*

  

*

  

3.23

3.38

TOID

10

11

31

33

5.38

    

*

*

2.95

3.76

TOID

11

12

44

37

5.08

*

  

*

*

2.32

6.17

TOID

11

17

16

33

6.21

*

  

*

  

3.25

8.86

TOID

16

17

32

23

5.97

*

  

*

*

0.09

2.82

TA (6.367, 5.370)

TA

2

9

97

14

5.63

  

*

*

  

7.68

3.43

TA

13

15

5

52

6.37

*

*

  

*

0.33

4.42
         

FEMALES

            

TOID (5.783, 4.837)

TOID

1

14

67

17

5.20

  

*

*

  

4.07

0.42

TOID

5

13

29

13

5.72

  

*

  

*

4.02

0.51

TOID

5

18

28

31

5.10

      

*

2.62

0.28

TA (5.691, 4.666)

TI (5.254, 4.177)

TI

3

12

74

9

4.24

*

  

*

  

2.26

3.03

TI

8

13

29

59

5.07

*

  

*

*

3.78

1.62

TTW (5.675, 4.545)

MET (6.781, 5.807)

MET

17

18

27

22

5.97

*

*

    

2.59

1.74

AMN (5.625, 4.943)

AMD (5.637, 4.688)

AMD

8

14

30

23

4.69

*

      

1.26

2.33
Table 2: Summary of the diet by epistasis interactions affecting cancer traits in male and female mice. Shown are the locations (Loc1 and Loc2) on each pair of chromosomes (Ch1 and Ch2) of the individual diet-dependent epistatic interactions affecting the tumor and metastatic traits that reached significance at the significant 0.05 (bolded values) or at the 0.2 (suggestive) genomewise level. Significant and suggestive threshold LOD scores are given in parentheses in the headings for each trait. Interactions of the epistatic components with diet (aad, add, dad, ddd) that reached significance at P < 0.05 are indicated by asterisks. For each interaction, LOD scores from tests of epistasis in mice fed the control (LOD-C) and high-fat diet (LOD-H) also are given.