Figure 2: Southern blot of EcoRI-digested genomic DNA in Family 8, using probe p13E-11. In proband (№ 105), proband’s daughter (№ 9) and proband’s granddaughter (№ 7) the EcoRI fragment sizes of 23 kb were revealed, respectively. In presymptomatic proband’s grandson (№ 8) and greatgranddaughter (№ 106) as well as in other proband’s relatives (№ 10. 11. 104. 107, 108) the EcoRI fragment sizes more than 50 kb were found.