| |
VT of 10 ml/kg (n=74) |
VT of 6 ml/kg (n=76) |
P–value |
| Age (years) |
58 (±17) |
63 (±15) |
0.06 |
| Male sex |
50 (68%) |
49 (64%) |
0.69 |
| APACHE–II score |
20 (±8) |
21 (±7) |
0.93 |
| SOFA |
8 (±4) |
7 (±3) |
0.19 |
| LIS |
1.2 (±0.6) |
1.3 (±0.6) |
0.08 |
| Underlying ALI risk factors: |
|
|
0.60 |
| -Sepsis |
7 |
4 |
|
| -Shock |
6 |
9 |
|
| -Pneumonia |
1 |
3 |
|
| -Aspiration |
|
1 |
|
| -Pancreatitis |
|
1 |
|
| -Trauma |
12 |
10 |
|
| Blood transfusion |
14 |
11 |
0.47 |
| Chronic alcohol abuse |
6 |
5 |
0.72 |
| Smoking history |
45 (61%) |
58 (76%) |
0.04 |
| Baseline CC16 (ng/ml) |
10.4 (5.2–21.6) |
8.8 (5.6–18.9) |
0.68 |
| Baseline SP–D (ng/ml) |
286 (159–518) |
396 (236–528) |
0.10 |
VT tidal volume; APACHE–II acute physiology and chronic health evaluation–II score; SOFA sepsis organ failure assessment score; LIS lung injury score; CC16 Clara cell protein; SP–D surfactant protein D |
