HPV+

HPV -

Rb

2/8 (25%)

6/7 (86%)*

P53

2/7 (29%)+

6/7 (86%)+

P16

7/7 (100%) strong+

6/7 (86%) weak+

Abbreviations: HPV: human papillomavirus, Rb: retinoblastoma, Sphk1:
sphingosine kinase 1, TGFβ: transforming growth factor beta
*One patient had insufficient tissue for determination of Rb staining results
+Two patients did not have enough tissue forp53 and p16 staining
Table 4: Expression of p53, Rb, p15, Sphk1, and TGF-β between HPV+ and HPVPatients
Analyzed by Immunohistochemistry.