Figure 2: Adenocarcinoma not otherwise specified (NOS): morphological (A-D) and immunohistochemical findings (E-F). A) The evidence of glandular and ductal features oriented for an epithelial origin of the neoplasia. The tumor was histologically graded as moderated differentiated adenocarcinoma (H&E, original magnification x4). B) A detail of A, with glandular representative histological findings and absence of a myoepithelial layer (H&E, original magnification x40). C-D) Focally, PAS positive material was observed within the neoplastic gland (C, H&E, original magnification x40; D, H&E, original magnification x20). E) The mass stained positive for cytocheratins AE1/AE3 (LSAB-HRP, nuclear counterstaining with haematoxylin, original magnification x10). F) The case has shown focal staining for p63 protein (LSAB-HRP, nuclear counterstaining with haematoxylin, original magnification x10).