Variable Nuclear Size Chi2
P-value
≤ 30 µm
n (%)
> 30 µm
n (%)
Total 35 (100) 27 (100) -
Cell differentiation - - 1.000
  Well/moderately differentiated 24 (69) 19 (70) -
  Poorly differentiated 11 (31) 8 (30) -
Histologic type - - .012
  Epithelial 35 (100) 22 (82) -
  Biphasic 0 (0) 5 (18) -
Nuclear/cytoplasmic ratio - - < .001
  Normal 33 (94) 9 (33) -
  Increased 2 (6) 18 (67) -
Mitotic count - - .001
  ≤ 4 34 (97) 17 (63) -
  > 4 1 (3) 10 (37) -
Atypical mitosis - - < .001
  Absent 35 (100) 16 (59) -
  Present 0 (0) 11 (41) -
Tumor necrosis - - < .001
  Absent 31 (89) 12 (44) -
  Present 4 (11) 15 (56) -
Pleomorphism - - .359
  Absent 29 (83) 19 (70) -
  Present 6 (17) 8 (30) -
Perineural invasion - - .279
Absent 32 (91) 22 (82) -
Present 3 (9) 5 (19) -
Lymph nodal involvement - - .223
Absent 33 (94) 22 (82) -
Present 2 (6) 5 (18) -
Depth of invasion - - .124
Infiltration limited to subserosal layer 24 (69) 13 (48) -
Infiltration beyond subserosal layer 11 (31) 14 (52) -
Chromatin Pattern - - < .001
    Uniform/granular 35 (100) 0 (0) -
Clear 0 (0) 27 (100) -
Nucleolar size - - < .001
≤ 3 µm 35 (100) 0 (0) -
> 3 µm 0 (0) 27 (100) -
Table 1: Correlations between nuclear size and 12 other histopathologic parameters.