| Family member |
Receptor |
Source |
Pathological role |
| IL-17(A) |
IL-17RA and RC |
TH-17 cells, CD8+ T cells, γδ T cells,
NK cells, NKT cells |
Involved in autoimmune pathology, neutrophil and monocyte trafficking and angiogenesis |
| IL-17B |
IL-17RB |
Cells of the gastrointestinal tract, pancreas and neurons |
Not identified |
| IL-17C |
IL-17RE |
Cells of the prostate and fetal kidney |
Not identified |
| IL-17D |
unknown |
Cells of the muscles, brain, heart,
lung, pancreas and adipose tissue |
Not identified |
| IL-17E (IL-25) |
IL-17RA and RB |
lymphocytes,
lung epithelial cells, alveolar macrophages, eosinophils, basophils, NKT cells, TH-2 cells, mast cells |
Induces TH-2 cell responses and therefore suppresses TH-17 cell polarization |
| IL-17F |
IL-17RA and RC |
TH-17 cells, CD8+ T cells, γδ T cells,
NK cells, NKT cells |
Neutrophil recruitment |
|
