Item (pg/ml)

Control
n=20

All RA patients
n=94

Early RA patients
n=22

Late RA patients
n=41

IL-1-ser

1,65±0,03

0,86±0,17

0,25 ± 0,30*

0,96 ± 0,20*◊

IL-6-ser

2,47±0,03

60,22±3,40 *

7,32 ± 4,33

104,55 ±41,20*◊

IL-10-ser

0,21±0,02

0,50±0,23

0,25 ± 0,23

0,45 ± 0,39

TNF-ser

2,17±0,07

3,69±1,18

3,97 ± 1,93

3,06 ± 1,46

IL-1-sin

1,95±0,91

10,06±2,28*

13,87 ± 2,60*

0,60 ± 0,40 *◊

IL-6-sin

3,48±1,12

1431,77±110,96*

1505,00±182,04*

1745,00±35,53*

IL-10-sin

1,11±1,02

7,26±1,18*

4,30 ± 2,60

10,82 ± 5,17*◊

TNF-sin

4,12±2,03

150,59±15,61*

101,00 ± 80,00*

158,21 ± 8,05*

Note: n — number of patients in each group. * — differences from the control were significant at р<0.05
Table 1: Cytokine profile in rheumatoid arthritis patients (mean ± SEM).