A: H and E section shows central crystalline deposits rimmed by multinucleated giant cells and inflammatory cells, and surrounded by soft tissue (100X magnification)
B: Multinucleated giant cells (thick arrow), macrophages (thin arrow) and neutrophils (arrow head) (400X)
C: Amorphous material and inflammatory cells including rare plasma cells (arrow head) in marrow (400X)
D: Polarized light microscopy demonstrates strongly negatively birefringent needle-shaped crystals and surrounding bony plate (40X)
