Macroaggregate PC Treatment U-STAT3 p-STAT3 N-JHu-C No Addition + -   rhTNF-α ↑* ↑*   MSU ↑* ↑*   AG-490 ↑* ↑*   rhTNF-α + AG-490 ↓** ↓**   MSU + AG-490 ↓** ↓** BMD-MSC-C No Addition + -   MSU ↔* ↔*   MSU+AG-490 ↑** ↔**   MSU+AG-490+Febuxostat ↑** ↑**   rhTNF-α ↑* ↑*   rhTNF-α+AG-490+Febuxostat ↓** ↔** *Increase (↑), Decrease (↓), No Difference (↔) compared to No Addition ** Increase (↑), Decrease (↓), No Difference (↔) compared to MSU, AG-490 or rhTNF-α

Table 3: U-STAT3 and p-STAT3 in normal juvenile chondrocyte pellet cultures (N-JHu-C) and pellet cultures initiated from MSCs (BMD-MSC-C).