mRNA X-linked miRNAs with poteintial to target 3' UTR FOXP3 miR-1184,miR-448,miR-502-5p,miR-508-3p,miR-532-3p,miR-542-3p,miR-892a CTLA4 miR-105/105ab,miR-1587,miR-3690,miR-3978,miR-4330,miR-4666-5p,miR-501-3p/502-3p,miR-502-5p,miR-505/505-3p,miR-542-3p,miR-548an,miR-892b CBL miR-105,miR-1321,miR-1587,miR-188-3p,miR-18b,miR-221,mir-222,miR-224,miR-23c, miR-361-3p,miR-361-5p, miR-363,miR-3672,miR-374a,miR-3978,miR-421,miR-424,miR-4328,miR-4329,miR-450b-5p,miR-452,miR-4768-3p,miR-936,miR-98 CBLB miR-221/222,miR-223,miR-450b-5p,miR-4768-5p, miR-507,miR-513a-5p,miR-513c/514b-5p,miR-548an,miR-891b SOCS1 miR-1912,miR-221/222,miR-361-3p,miR-766, miR-98 SOCS2 miR-1264,miR-188-3p,miR-224,miR-3202,miR-3690,miR-374c,miR-421,miR-448/448-3p,miR-452, miR-507,miR-510,rniR-513a-3p,miR-514/514b-3p,miR-542-5p,miR-890 SOCS3 miR-1184,miR-1321,miR-1468,miR-2114,miR-221/222,miR-3202,miR-361-3p,miR-384/384-3p,miR-3915,miR-3978,miR-450b-3p,miR-508-3p,miR-510,miR-718,miR-764,miR-766,miR-767-3p,miR-890 PDCD1 miR-188-3p,miR-188-5p,rniR-3202,rniR-361-3p,rniR-3672,miR-374ab,miR-3915,rniR-4428,miR-510,miR-532-3p,miR-548m,miR-766

3’UTR region of the immunosuppressive genes were scanned using TargetScan to identify potential miRNA binding sites. X-Chromosome encoded miRNAs were selected from the list of miRNA predicted to target each gene. Highlighted in bold are the miRNAs we have identified in as overexpressed in CD4+ T cells of women with lupus in respect to men with lupus. MiRNAs overexpressed in experimentally demethylated CD4+ T cells are underlined.

Table 1: X-linked miRNAs predicted to target immune suppressive genes.