Control

lcSSc

dcSSc

Estimate

Estimate

p-value

Estimate

p-value

sAng-1

9 207 ± 808

10 622 ± 1 662

0.7381

13 889 ± 2 201

0.1934

sAng-2

1 864 ± 122

4 944 ± 941

<0.0001

3 982 ± 498

0.0039

sTie-2

30.8 ± 1.0

37.7 ± 2.8

0.0082

37.7 ± 2.1

0.2324

Endostatin

143 ± 12

261 ± 33

0.0008

259 ± 32

0.0020

VEGF

195 ± 20

290 ± 74

0.5153

270 ± 66

0.6953

VEGF-R1

170 ± 10

173 ± 20

0.8288

178 ± 20

0.3750

sE-selectin

18.2 ± 1.2

34.0 ± 3.9

0.0003

30.5 ± 3.1

0.0840

sL-selectin

906 ± 35

961 ± 61

0.2753

755 ± 57

0.0273

sICAM-1

233 ± 12

314 ± 49

0.1956

316 ± 29

0.0840

sVCAM-1

1 152 ± 57  

1 443 ± 164

0.2101

1 205 ± 115

0.6250

EMP

111 ± 13

116 ± 21

0.6794

200 ± 50

0.3223

PMP

300 ± 79

161 ± 51

0.0020

120 ± 24

0.4316

Values are the mean ± SE. Unit of measurement is pg/ml for sAng-1, sAng-2, VEGF, and VEGF-R1. Unit of measurement is ng/ml for sTie-2, Endostatin,  sE-selectin,  sL-selectin, sICAM-1, and sVCAM-1 Microparticles are measured in counts per μl. The p-values are for paired testing of no location shift between cases with matched controls by the exact Wilcoxon signed rank test. One male dcSSc case did not match a female control and so both were dropped from the Wilcoxon signed rank tests  The p-values in bold are less than 0.05/24 = 0.0021.