lcSSc

dcSSc

ILD

Yes

No

Yes

No

p-value

p-value

sAng-1

13 076 ± 2 823

8 413 ± 1 575

0.9682

14 622 ± 2 965

12 607 ± 3 571

0.9273

sAng-2

6 633 ± 1 798

3 423 ± 488

0.2428

4 569 ± 683

2 954 ± 294

0.3152

sTie-2

36.8 ± 3.9

38.4 ± 2.0

0.1333

35.1 ± 2.1

42.2 ± 6.8

0.6485

Endostatin

296 ± 54

230 ± 38

0.4967

279 ± 50

225 ± 20

0.9273

VEGF

418 ± 146

176 ± 29

0.0947

307 ± 102

207 ± 38

0.7879

VEGF-R1

191 ± 36

157 ± 20

0.7197

178 ± 33

178 ± 7

0.7879

sE-selectin

43.3 ± 6,2

25.7 ± 3.3

0.0535

33.7 ± 4.1

25.2 ± 3.6

0.3152

sL-selectin

960 ± 101

963 ± 78

0.7197

673 ± 44

899 ± 111

0.1091

sICAM-1

343 ± 104

288 ± 22

0.4002

326 ± 37

298 ± 54

0.9273

sVCAM-1

1 616 ± 306

1 287 ± 146

0.5490

1 281 ± 172

1 072 ± 91

0.5273

EMP

97 ± 23

132 ± 35

0.6607

277 ± 63

66 ± 9

0.0121

PMP

120 ± 32

198 ± 94

0.8421

146 ± 32

76 ± 27

0.1636

Values are the mean ± SE. Unit of measurement is pg/ml for sAng-1, sAng-2, VEGF, and VEGF-R1. Unit of measurement is ng/ml for sTie-2, Endostatin, sE-selectin, sL-selectin, sICAM-1, and sVCAM-1. Microparticles are measured in counts per μl. The P values are for paired testing of no difference of location between cases with and without lung fibrosis within each disease type by the exact Mann-Whitney test.

Table 3: Comparison of mean concentrations of circulating factors by ILD and disease type.