lcSSc

dcSSc

Putative PAH

Present

Absent

Present

Absent

p-value

p-value

sAng-1

11 770 ± 2,901

9 588 ± 1 737

0.6607

14 975 ± 4 270

13 269 ± 2 701

0.6485

sAng-2

7 360 ± 1,641

2 770 ±    325

0.0076

4 199 ± 1 043

3 858 ± 576

0.9273

sTie-2

41.0 ± 2.6

34.7 ± 3.0

0.1128

36.4 ± 2.2

38.4 ± 4.4

0.7879

Endostatin

308 ± 51

219 ± 39

0.1333

256 ± 49

261± 46

>0.9999  

VEGF

431 ± 145

163 ± 23

0.0435

406 ± 165

193 ± 30

0.1091

VEGF-R1

189 ± 36

159 ± 21

0.5490

234 ± 32

146 ± 18

0.0424

sE-selectin

42.7 ± 6.7

26.3 ± 2.8

0.0535

31.1 ± 7.7

30.2 ± 2.8

0.9273

sL-selectin

948 ± 105

973 ± 73

0.5490

814 ± 48

721 ± 86

0.1636

sICAM-1

388 ± 95

248 ± 30

0.2775

335 ± 36

305 ± 42

0.6485

sVCAM-1

1 844 ± 283

1 082 ± 856

0.0101

1,157 ± 104

1 232 ± 177

0.7879

EMP

86 ± 23

142 ± 33

0.2775

150 ± 74

229 ± 68

0.6485

PMP

209 ± 107

118 ± 20

0.6607

83 ± 9

142 ± 36

0.3152

Values are the mean ± SE. Unit of measurement is pg/ml for sAng-1, sAng-2, VEGF, and VEGF-R1. Unit of measurement is ng/ml for sTie-2, Endostatin,  sE-selectin,  sL-selectin, sICAM-1, and sVCAM-1. Microparticles are measured in counts per μl. The p-values are for paired testing of no difference of location between cases with and without TTE RVSP ³ 35 mm Hg within each disease type by the exact Mann-Whitney test signed rank test.