Abbreviations: ROI: Region-of-Interest; a.u: Arbitrary Units.

Figure 4: Mapping and time course of the response in T2* signal during respiratory challenge (carbogen stimulus for data acquisition, 0.01 threshold for data analysis [A-F] in the carrageenin-injected (arthritic) knee of a rabbit model. Panels B, D, F show changes in the on-and-off signal intensity in the corresponding region-of-interest for 60-second interval paradigms of normoxia (off) and hyperoxia (on) at the time of the experiment. The red lines of the graphs indicate the averaged time courses of differences in BOLD signal intensity in the perisynovial tissue that were measured and the blue lines the superposed on- and –off Talairach-based paradigms that were used for calculations.