Table 1

	Increased Temperature				Decreased Temperature
	Arthritic	Contralateral	Non-Injection	P-value	Arthritic	Contralateral	Non-Injection	P-value
Diff_on_off_0.2, 95% O2+5% CO2, 60 sec	-0.09 (0.09)	-0.02 (0.06)	-0.03 (0.06)	P= .08 (arthritis vs contralateral); P = .20 (arthritis vs control)	0.01 (0.18)	-0.07 (0.48)	-0.03 (0.06)	P= 0.29 (arthritis vs contralateral); P = 0.86 (arthritis vs control)
PT% 0.2, 95% O2+5% CO2, 60 sec	-0.46 (2.26)	-0.02 (0.40)	0.11 (0.28)	P= .08 (arthritis vs contralateral); P = .09 (arthritis vs control)	0.26 (1.04)	-0.07 (0.37)	0.07 (0.32)	P= 0.35 (arthritis vs contralateral); P = 0.62 (arthritis vs control)
Diff_on_off_0.01, 95% O2+5% CO2, 60 sec	-0.16 (0.42)	-0.04 (0.16)	-0.03 (0.12)	P= .15 (arthritis vs contralateral); P = .34 (arthritis vs control)	-0.005 (0.41)	-0.03 (0.32)	-0.03 (0.19)	P= 0.87 (arthritis vs contralateral); P = 0.90 (arthritis vs control)
PT% 0.01, 95% O2+5% CO2, 60 sec	-0.35 (0.94)	0.09 (0.23)	0.12 (0.17)	P= .13 (arthritis vs contralateral); P = .13 (arthritis vs control)	0.03 (0.25)	0.008 (0.30)	0.15 (0.31)	P= 0.90 (arthritis vs contralateral); P = 0.52 (arthritis vs control)

P values represent comparisons of BOLD MRI signal changes between arthritic and contralateral; and arthritic and non-injection joints.
Percentual BOLD MRI signal changes are obtained using the formula: [(BOLD signal change at a given local temperature state minus BOLD signal change at baseline) /
BOLD signal change at baseline] x 100.
Values are provided as relative (BOLD measurement at increased or decreased local joint temperature minus BOLD measurement at baseline / BOLD measurement at
baseline) values.
A negative value represents a signal change loss between baseline and the given temperature state and a positive value represents a corresponding signal change
increase.
Abbreviations:diff_on_off: Difference in on and Off changes; PT%: Percentage of Activated Voxels; sec: Seconds

Table 1: Mean (standard deviation) change in BOLD MRI measurements (=BOLD signal change at a given local temperature state minus BOLD signal change at baseline / BOLD signal change at baseline) in arthritic (injected), contralateral to injected joints and non-injection joints upon stimulus of increased and decreased local temperature using 4 different paradigms for BOLD MRI data acquisition and analysis.