Table 2

	BOLD MRI Parameters
Knees	Diff_on_off_0.2, 95% O2+5% CO2, 60 sec	Diff_on_off_0.01, 95% O2+5% CO2, 60 sec
	Standardized Response Mean
Arthritic	-0.22 – Small	0.03
Contralateral	-0.48 – Small	0.07
Non-injection	-0.01	0.40 – Small
Knees	PT% 0.2, 95% O2+5% CO2, 60 sec	PT% 0.01, 95% O2+5% CO2, 60 sec
	Standardized Response Mean
Arthritic	0.54 – Moderate	0.16
Contralateral	1.93 – Large	1.75 - Large
Non-injection	0.56 - Moderate	0.40 – Small

Abbreviations: diff_on_off: Difference in on and Off changes; PT%: Percentage
of Activated Voxels

Table 2: Standardized response mean for assessment of internal responsiveness of relative BOLD MRI measurements at increased local temperatures using different sets of BOLD MRI parameters in arthritic, contralateral and non-injection knees.