Table 3

	BOLD MRI Parameters
Knees	Diff_on_off_0.2, 95% O2+5% CO2, 60 sec	Diff_on_off_0.01, 95% O2+5% CO2, 60 sec
	Standardized Response Mean
Arthritic	0.45 - Small	0.41 – Small
Contralateral	-0.12	0.03
Non-injection	-0.48 - Small	0.38 - Small
Knees	PT% 0.2, 95% O2+5% CO2, 60 sec	PT% 0.01, 95% O2+5% CO2, 60 sec
	Standardized Response Mean
Arthritic	0.58 - Moderate	0.04
Contralateral	0.73 - Moderate	0.75 - Moderate
Non-injection	0.37 - Small	0.23 - Small

Abbreviations: diff_on_off: Difference in on and Off changes; PT%: Percentage
of Activated Voxels

Table 3: Standardized response mean for assessment of internal responsiveness of relative BOLD MRI measurements at decreased local temperatures using different sets of BOLD MRI parameters in arthritic, contralateral and non-injection knees.