Figure 3: A. Modification of gene expression patterns under different culture condition (MSC – undifferentiated monolayer, MM – differentiated micromass culture, Gel – gelatin hydrogel, GHA – gelatin hydrogel with high molecular weight hyaluronan incorporated, HSA – human serum albumin hydrogel, HSA-HA – human serum albumin hydrogel with high molecular weight albumin incorporated. After four weeks of chondrogenic differentiation there is generally no difference in the gene expression levels among the five three-dimensional cultures, with the exception of collagen type 1 expression in gelatin hydrogels (* = significant, p<0.05, one way ANOVA on ranks). B. Morphological appearance of MSCs chondrogenically differentiated in Gel (top) and HSA (bottom) hydrogels. Bars = 500 μm.