Figure 1: A schematic representation of a throat infection by S. pyogenes and immune response. Interactions between molecules secreted by several susceptible alleles of diverse genes (Table 1) involved with both the innate and adaptive immune response. Phagocytic cells bind to the S. pyogenes through TLR2 and mannose binding lectinand ficolins receptors via N- acethylglucosamine molecule (GlcNAC).