| Receptor |
References |
Location |
Agonist |
Adapter |
Human lymphocytes |
| TLR1 |
[11-13] |
Cell surface |
Bacterial lipoproteins |
MyD88 |
Monocytes |
| |
[14,15] |
Intracellular |
Lipopeptides |
Tirap |
B cells |
| |
|
|
|
|
MDCs |
| TLR2 |
[11,12,16] |
Cell surface |
Peptidoglycan |
MyD88 |
Monocytes |
| |
[17] |
Intracellular |
Lipoteichoic acid |
Tirap |
Macrophages |
| |
|
|
Lipoarabinomannan |
|
MDCs |
| |
|
|
Lipoprotein |
|
|
| TLR3 |
[11,12,18] |
Intracellular |
Double-stranded RNA |
TRIF |
NK cells |
| |
|
|
Poly I:C |
TRAM |
MDCs |
| TLR4 |
[11,12,16] |
Cell surface |
Lipopolysaccharide (LPS) |
MyD88 |
Monocytes |
| |
[19,20] |
|
|
Tirap |
Macrophages |
| |
|
|
|
TRIF
TRAM |
MDCs |
| TLR5 |
[11,16] |
Cell surface |
Flagellin |
MyD88 |
Monocytes |
| |
|
|
|
|
Macrophages |
| |
|
|
|
|
MDCs |
| TLR6 |
[11,21] |
Cell surface |
MALP-2 |
MyD88
Tirap |
MDCs |
| |
|
|
Mycoplasmal |
|
B cells |
| |
|
|
Soluble tuberculosis factor (STF) |
|
|
| |
|
|
Phenol-soluble modulin (PSM) |
|
|
| |
|
|
Diacyllipopeptides |
|
|
| TLR7 |
[1,4,11] |
Intracellular |
Single-stranded RNA |
MyD88 |
pDCs |
| |
[15,22,23] |
|
Loxoribine |
|
B cells |
| |
[24,25] |
|
Imidazoquinoline |
|
|
| |
|
|
Bropirimine |
|
|
| TLR8 |
[1,11,26] |
Intracellular |
Single-stranded RNA |
MyD88 |
Monocytes |
| |
[27,28] |
|
|
|
Macrophages |
| |
|
|
|
|
MDCs |
| TLR9 |
[1,11,25] |
Intracellular |
Unmethylated CpG ODNs |
MyD88 |
pDCs |
| |
[29] |
|
Membrane microparticles |
|
B cells |
| TLR10 |
[11,30] |
Intracellular |
Pam(3) CSK(4) |
MyD88 |
B cells |
|