First consultation

Second consultation

Third consultation

 

Number of patients with complaints

Number of patients with complaints

Number of patients with complaints

Lifestyle

N=78

Lifestyle + PPI

N=70

Lifestyle + PPI + Alginate
N=89

Lifestyle

N=65

Lifestyle + PPI

N=59

Lifestyle + PPI +
Alginate
N=71

Lifestyle

N=46

Lifestyle + PPI

N=43

Lifestyle + PPI + Alginate
N=55

 

Subjective complaints – each complaint was described as ‘a severe problem’ according to RSI

“My throat/voice does not function”

78

69

89

56

51

57

33

25

37

Sensation of something sticking in your throat or a lump in your throat (globules)

53

48

67

30

35

34

25

19

23

Hoarseness or a problem with your voice

61

54

70

48

35

45

24

17

29

Excess throat mucous or postnasal drip / clearing your throat

66

65

75

48

42

53

30

28

34

Breathing difficulties or choking episodes (larynx spasms and hick ups)

31

31

34

19

23

22

7

9

11

Heartburn, chest pain, indigestion / stomach acid coming up, pain or burning feeling in the throat

47

43

59

26

23

23

12

9

14

Difficulty swallowing food, liquids, or pills (dysphagia)

36

32

48

18

16

20

16

13

15

Coughing after you ate or after lying down, troublesome or annoying cough

48

40

53

31

28

35

14

13

19

Total number of symptoms

Mean

5.37

5.46

5.56

3.54

3.76

3.34

2.06

1.90

2.17

SD

1.26

1.28

1.19

2.39

2.27

2.27

2.46

2.26

2.30

Difference to Lifestyle
(=LS) means [95% CI]

 

 

 

 

0.17
[-0.54; 0.88]

-0.32
[-0.99; 0.35]

 

 

 

p-value1

 

 

 

 

0.65

0.35

 

 

 

1Comparison of means between treatment groups to Lifestyle treatment group. The test is a two-sided test in the linear statistical model that includes baseline number of symptoms as a covariate and treatment as a fixed effect.(CI =confidence interval)
Table 2: Subjective complaints summary and analysis.