| Study, Year |
Country |
Sample |
Cases
(n) |
Patient Age Range, Mean or Median |
Overall and type-specific prevalence, n (%) |
| |
|
|
|
|
Any HPV |
16 |
11 |
| Europe |
|
|
|
|
|
|
|
| Mammas, 2006 [46] |
Greece |
PE |
64 |
2-14,
mean = 7.5 |
61
(9%) |
|
|
| Chen, 2005 [47] |
Finland |
FF |
212 |
1-72,
mean = 23.2 |
132 (6%) |
13
(100%) |
|
| Klussmann, 2001 [36] |
Germany |
PE |
143 |
20-65,
median = 52 |
0 |
|
|
| Mellin, 2000 [40] |
Sweden |
PE |
10 |
18-48,
mean = 27 |
0 |
|
|
| Niedobitek, 1990 [39] |
England |
PE |
30 |
47-80,
median = 60 |
0 |
|
|
| North America |
|
|
|
|
|
|
|
| Ernster, 20094 [48] |
USA |
PE |
226 |
21≤ |
0 |
|
|
| Luginbuhl, 2009 [41] |
USA |
PE |
41 |
36-845 |
0 |
|
|
| Pintos, 2008 [14] |
Canada |
Brush/ gargle6 |
129 |
25-84 |
6
(5%) |
|
|
| Sisk, 2006 [49] |
USA |
FF |
50 |
3-12 |
2
(4%) |
|
1
(2%) |
| Strome, 2002 [43] |
USA |
PE |
48 |
-- |
3
(6%) |
3
(100%) |
|
1Study included both tonsillar and adenoid tissue, and authors did not state which subtypes were isolated from tonsillar tissue vs. adenoid tissue. Only the overall prevalence in tonsillar tissue was given. However, the authors state that primarily type 16 was isolated and less frequently HPV 11. No HPV 18 or 33 were isolated.
2 Note that the study included patients across a broad age range. The prevalence was highest in preschool children (11.5%) and young adults (9.3%).
3 Both tonsils tested for each patient in this study.
4 Ernster et al. have used the same technique in a series of oropharyngeal SCC and they detected HPV16 in 69% (50/72) [40].
5 Ages of controls not given, however authors state that they were age-matched to the TSCC patients included.
6 Brush sample obtained by swabbing multiple sites in the buccal cavity was combined with a gargle specimen. |
