Figure 5:Pattern of Fos expression in CIC. (A) In ipsilateral CIC (CICi) only a few Fos positive nuclei are visible. The dashed line marks the region of interest (ROI). Scale bar: 500 μm. (B) In contrast, in contralateral CIC (CICc) Fos positive nuclei (black dots) emerged in regions tonotopically corresponding to the intracochlear stimulation site. The insets in (A+B) show Fos positive nuclei (black dots, inset A) and how they were identified by image analysis (white dots, inset B). Scale bar: 20 μm. Shown are the patterns of a nimodipine-treated rat. (C+D) Fos expression induced by various experimental setups within the non-treated (C) and the nimodipine-treated group (D). For significant differences against control (a) see text. (E) Direct comparison of the effect of nimodipine on Fos expression for each experimental setup. (***): p < 0.001; (**): p < 0.01; (*): p < 0.05; Co: Control group; nimo: nimodipine-treated group; Impl: dummy implantation of electrode carrier; i: ipsilateral; c: contralateral.