Zahra Hussain Alshabeeb
Objective: The aim of our study was to examine immunoreactivity between AβP-42, toxic chemicals, and food proteins thatwould be involved in AD. Methods: We applied monoclonal anti-AβP-42 to a range of chemicals bound to human albumin (HSA) and 208 different food extracts.
Keywords:
AβP-42; Amyloidogenesis; Alzheimer’s Disease; Toxins; Dietary Proteins; Immunoreactivity; Neurodegeneration Immunoreactivity to Common Foods:
Now that we have some understanding of Immunology under our belts, we will get to the meat of what my clients tend to care about – immunoreactivities to common foods and how this may be a trigger for autoimmunity or one’s own immune system seeing self-tissue as a pathogen. This is a very big deal as it is estimated that over 50 million Americans suffer from some kind autoimmunity (comparatively, heart disease “only” affects upwards of 22 million Americans) and the occurrence of autoimmunity is growing exponentially. It is now believed that around 30% of autoimmunity is due to genetic predisposition. But, this implies that 70% of autoimmune cases are potentially caused by environmental and lifestyle triggers – the main culprits being intestinal permeability, infections, and chemical exposures.
“Bacterial toxins, chemicals, foods, and undigested proteins and peptides can induce systemic food immune reactivity by causing failure of immune tolerance. Immune tolerance is the immune system’s ability to recognize what is harmful and what is not. If immune tolerance is lost, then inflammation ensues and autoimmunity can occur.”
The digestive system sees over 1 ton of food every year and contains north of 70% of our immune cells. Your gastrointestinal tract also has more contact with the surface world than your skin and this mucosal lining is constantly being exposed to potential antigens.
The reason our body doesn’t wreck shop on all this food stuff all the time is due to oral tolerance which occurs through the deletion or immunosuppression of reactive immune cells.
Reacting to common food items isn’t normal and may be due to impaired immunological development (which is outside the scope of this post and revolves around the hygiene hypothesis, maternal diet, how one was born, breast feeding, and also the infant gut microbiota) or an immune system that’s out of balance (cough low vitamin D) and over stimulated (SAD).
There is a lot going on above, but we can use our newfound understanding of immunology and begin to grasp how this all works.
Materials and Methods
Monoclonal antibodies
Commercially available antibodies were purchased from different companies. Rabbit monoclonalanti-amyloid-β1-42(fibrilsequence DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA) produced by Abcam’s RabMab® technology was purchased from Abcam. This antibody reacts strongly to human Aβ 42 monomers, oligomers and fibrils, but not with human muscle fibrils. Additional information about the specificity of this antibody is provided in the Abcam package insert (ab201061) and in an article by Hatami et al. [53]. Affinity-purified mouse anti-amyloid-β1-42 was purchased from BioLegend, San Diego, CA USA. This antibody reacted strongly with formalin-fixed, paraffin- embedded diseased human brain tissue.
Binding of phthalate to HAS:
Preparation of diethyl phthalate was done according to the method described by Zhou et al. [54]. Briefly, 2 mg of diethyl phthalate was dissolved in methanol and added dropwise to 25 mg of HSA dissolved in 5 mL of 0.14 Tris-HCl buffer.
Preparation of dietary antigens: Food antigens were prepared from products purchased from the supermarket in both raw and cooked forms. For that preparation, 10 g of nutrient was put in a food processor using 0.1 M of phosphate buffer saline (PBS) at pH 7.4. The mixer was turned on and off for 1 h and then kept on the stirrer overnight at 4°C. After centrifugation Citation: Vojdani A, Vojdani E (2018) Immunoreactivity of Anti-AβP-42 Specific Antibody with Toxic Chemicals and Food Antigens. J Alzheimers Dis Parkinsonism 8: 441. doi: 10.4172/2161-0460.1000441 Page 3 of 11 Volume 8 Issue 3 • 1000441 J Alzheimers Dis Parkinsonism, an open access journal ISSN:2161-0460 at 20,000 g for 15 min, the top layer, which contained oil bodies, was discarded The liquid phase was removed and dialyzed against b0.01 M of PBS using dialysis bags, with a cutoff of 6,000 kDa. Dialysis was repeated three times to ensure all small molecules were removed. After dialysis, all samples were filtered through a 0.2 micron filter to remove any debris. Protein concentrations were measured using a kit provided by Bio-Rad (Hercules, CA, USA). Different peptides were purchased from Bio-Synthesis (Lewisville, TX, USA). Lectin and agglutinins including pea lectin and lentil lectin were purchased from SigmaAldrich (St. Louis, MO, USA).
Conclusion:
Depend on these results, we hypothesized that reaction between AβP-42 antibody with chemically bound to HSA and numerous food antigens might play a lead role in Alzheimer’s disease (AD). These anti-AβP antibodies might be derived from protein mis folding like to β-amyloid, or from antibodies to various food antigens that cross-react with AβP-42. Removal of toxic chemicals and food items that share a homology with β-amyloid is also recommended at least for patients within the early stages of AD. Therefore, the role of AβP-42 cross-reactive foods and chemicals bound to HSA in neurodegeneration should be investigated further.
Results:
We have found that anti-AβP-42 reacts from moderately to strongly with mercury-HSA, dinitrophenyl-HSA (DNP-HSA), phthalate-HSA, and aluminum-HSA, but not to many other tested chemicals bound to HSA nor to HSA alone. This antibody also reacted with 19 out of the 208 food antigens utilized in the assay. One example of a food that reacted strongly with anti-AβP-42 in our study was canned tuna, although raw tuna reacted only moderately.
We had a huge success with the completion of 6th Global Experts Meeting on Parkinsons and Movement Disorders Webinar on October 21-22, 2020. The significance of the meeting was achieved due to the accumulation of all the related group of spectators of research scientists to share their Knowledge, Research work, Technologies, and furthermore trade of worldwide Information towards the correct crowd at ideal time. Congress has received a generous response from all over the world. This has been organized with the aim of endorsing the development of new perceptions and ideas for investigating the high level of knowledge reached by scientific community in the field of Neuroscience.
The conference was organized around the theme “Novel insights of Clinical Perspectives in the treatment of Parkinsons and Movement disorders”. The congress entrenched a firm relation of future strategies in the field of Neurosciences.
We would like to thank each and every participant of Euro Parkinsons 2020 webinar to make this a huge success. And special thanks to media partners for the promotion of our event.
The ConferenceSeries Neuroscience Conferences aim to bring together the prominent researchers academic scientists, and research scholars to exchange and share their experiences on all aspects of Neurosciences. It is conjointly a knowledge domain platform for researchers, practitioners and educators to gift and discuss the foremost recent advances, trends, and issues in addition as sensible challenges and solutions adopted in the fields of Neurosciences.
Parkinson’s disease is a dynamic neurological disorder that influences how the individual moves, including how they talk and compose. This disease is caused by low dopamine levels. Various useful treatments, utilizing therapies (physiotherapy), surgery and medications have recognized neurological disorders and changes in the patient group. People with Parkinson’s disease also experience stiffness and they find abnormality in carrying out the movements as rapidly as before- this is known as bradykinesia. Parkinson’s disease market in US is expected to grow at a rate of 5.3% from sales of $1.1 billion in 2012 to $1.3 billion in 2022. Approximately 1 million adults in Asia are suffering from Parkinson’s disease, from where 60,000 were diagnosed annually. An estimated of 30%-50% of PD patients mainly suffering from depression. United States is in the fourth position in considering the death of people due to Parkinson’s disease. African Americans have the highest death rate of 66.4% followed by whites of 64.6%, Hispanic with 55.4% and Asians with 50.8%. Parkinson’s disease strikes 50% more men than women. The economic burden of Parkinson’s disease on patients and their families in the Asia is about $9.4 billion.
Parkinson’s disease is caused by the progressive impairment or deterioration of neurons (nerve cells) in an area of the brain known as Substantia Nigra.
OBJECTIVE:
METHODS:
RESULTS:
Fast growing potent Dopaminergic cell lines have been produced with long survival in cell culture. In animal studies (6-OHDA treated Rat model for PD), 4 different clones showed very effective reversal of the disease.
CONCLUSIONS:
Highly potent modified neural cells have been produced in our lab to treat PD patients.
Parkinson’s disease, an age related neurodegenerative disorder, is characterized by progressive loss of dopaminergic neurons in substantia nigra pars compacta of the mid brain and projecting neurons in striatum. Recently, several studies regarding parkinson’s disease have proven the role of oxidative stress in neurodegeneration and neuroinflammation. In this context, our study evaluates the neuroprotective effect of Tinospora Cordifolia Aqueous Extract (TCAE) in parkinsonian mice. From the immunohistochemistry and western blot analysis, it is evident that TCAE inhibits the MPTP-induced activation of NF-κB and its associated pro-inflammatory cytokines. Through, Real time PCR analysis it was revealed that pro-inflammatory cytokines were found to be up regulated in MPTP intoxicated mice while TCAE treatment significantly restored their levels. In addition, the expression level of IL-10 was found decreased in diseased condition which was further restored by TCAE treatment. Tyrosine hydroxylase, an important enzyme which is used as marker in parkinson’s disease, its expression was found to be reduced in MPTP mice while on giving TCAE, its level was significantly restored. Our result clearly indicates that Tinospora cordifolia provides neuroprotection against MPTP induced nigrostriatal dopaminergic neurodegeneration and shows potent anti-inflammatory activity.
Introduction: Clinical profile and severity correlation of ataxia patients in our population is still varied . This study is taken up to explore this aspect. Methods - A cross-sectional study was conducted at XXX. Clinical parameters with severity correlation( SARA scale ) in selected patients was determined.
Results: In 188 patients , 127 had cerebellar ataxia(SCA 2, 3, 1 ,6 ,12 , MSA C , Wilsons disease) , 42 had sensory ataxia mainly Sensory ataxic GBS, CIDP variant(CISP) , Sjogrens and 19 had Mixed cerebellar sensory ataxia (Multiple sclerosis , Vitamin E deficiency ). Cerebellar ataxias had higher disability at presentation ( mean SARA score- 21.87) than mixed ataxias ( SARA – 19.68). Increase in SARA score was seen more in mixed ataxias (3.64) than cerebellar ( 3.01) . Disability progression is more in MSA C and SCA 2 has lesser degree of progression ( despite highest SARA score- 28.5 at presentation).
Stress is a natural part of our lives and healthy levels help us with creativity, reaching our goals and maintaining overall drive. Increased stress levels erode our health, productivity and overall happiness. Chronic stress is becoming an epidemic of the twenty-first century. To combat this state of affairs many began exploring the benefits of mindfulness as an antidote to chronic stress. Thirty years of research looking at the effects of mindfulness, as well as the neuroscience of mindfulness, offer compelling evidence to support the use of mindfulness practices. Some benefits of practicing mindfulness are stronger focus, better memory, staying calmer under stress, enhanced concentration and executive functioning, improved overall mental and physical health. In 2015, the School of Nursing at UBC Okanagan began offering a smartUBC to all first-year students in a mandatory Relational Practice course. The rationale was two-fold: to provide undergraduate students with mindfulness skills and capacities to help them navigate and succeed in their first year of university as well as stress management and resiliency techniques for their nursing practice.
The National Mental Health Survey (2014-2016), one of the largest mental health “Research and Action” oriented study undertaken in recent times across 12 states of India reported a high weighted lifetime prevalence of 5.25 in depressive disorders and 1.41 in severe mental illness (n=34802). The WHO also states that by the year 2020, Depression will be the most prevalent condition in the world. With this high rise in NCDs (Non-communicable diseases), a large proportion of people with mental illness also have co-existing medical conditions such as obesity, diabetes mellitus, hypertension, etc. adding the disability. In this background, there exists a high level of stigma towards this illness. Individuals with mental illness recover better with lesser relapse rates when they are engaged in work
Drug-induced kidney injury is the causative of acute kidney failure. Amifostine loaded silica nanoemulsion was synthesized using water/oil emulsion with the help of ultra-sonication waves. The nanoemulsion was prepared using Tetraethyl Orthosilicate [TEOS], Cetyltrimethylammonium Bromide [CTAB], Castor Oil [CAO] and Amifostine [AMF] as a source for silica, surfactant, extra stabilizing agent and a model drug respectively. The as synthesized nanoemulsion of silica and silica loaded with amifostine [SiNPs@AMF] was examined via Transmission Electron Microscopy [TEM] and Dynamic Light Scattering [DLS] in terms of particles shape and hydrodynamic average size.
Research shows that the extent of employment mobility among people with psychiatric disabilities is low, even though most of them want and can work. While supported employment has significantly improved competitive work outcomes throughout the world, it leads to sustained work in only 25-35% of persons with psychiatric disabilities, while most persons lose jobs within a few weeks/months after beginning them or never obtain competitive work. Shekulo Tov is a non-profit organization and a service supplier for the Israeli Ministry of Health for more than 3,000 service users. Shekulo Tov’s Integrative Unit Model represents an essential change of perception vis-à-vis vocational rehabilitation. It is a formative shift from the two sequential approaches of “train, then place” or “place then train” to a simultaneous approach of “train & place".
The purpose of this study was to evaluate the effectiveness of cognitive behavioral stress management intervention on general health and quality of life in patients with cardiovascular diseases in Ahvaz. The available samples were used for selecting the subjects so that 30 individuals from the cardiovascular patients were selected to participate in the survey and were divided randomly into two groups, experimental and control every 15 persons. All the participants answered the General Health Questionnaire (GHQ-28) and the World Health Organization Quality of Life Brief Questionnaire (Who-QOL-BRIEF). The experimental group received 10 sessions of stress management training by the cognitive- behavioral method. At the posttest stage, the responses of both groups to the questionnaires were recorded again.
Mental health is among the most vexing social and medical problems of our era. Medications are effective, though access, costs, stigma, side effects, and health risks may deter utilization. Likewise, professional psychotherapy helps yet is unaffordable and unavailable to many and, even when empirically based treatments can be accessed, relapse, mortality, and morbidity are the rule with mental disorders. Therefore, there is an urgent need for affordable and accessible treatment options. We all are baffled by the thought that the processes of non-pharmacological interventions that is so successful in the western, just does not find any takers in the eastern world. Despite so much evidence in favor of the number of therapies and techniques, still, these continue to be on the fringes of the eastern mental health treatment. Alternative or complementary medical and spiritual approaches are promising and are associated with excellent patient acceptance.
DOI: 10.37421/2572-0791.2021.7.003
DOI: 10.37421/2572-0791.2021.7.002
DOI: 10.37421/2572-0791.2021.7.004
DOI: 10.37421/2572-0791.2021.7.001
Fatimah Almeathem*, Fatimah Alsultan, Ahoud Alharbi, Nouf Adawi, Noura Al-Ahmad, Fai Alhotan, Raghad Alshamlan and Roaa Almazyad
DOI: 10.37421/2572-0791.2021.7.005
Objectives: To determine the prevalence of mental health disorders among college students in Saudi Arabia, to compare between medical students and non-medical students, to identify the factors that affect mental health and to assess the impact of students’ academic performance in this population. To determine the prevalence of obsessive compulsive disorder among medical and non-medical students
Methods: A cross-sectional study that is carried out among college students of both medical and non-medical specialties in different Saudi colleges. Data was collected via filling an online questionnaire for the socio- demographic characteristics, several aspects of academic life, Depression Anxiety Stress Scale (DASS 21) and Arabic Scale of Obsession-Compulsion (ASOC) that was posted on social media and sent by E-mails
Results: The data revealed high levels of mental disorders among college student. Risk factors included: gender and GPA, females and lower GPA appeared to carry a greater risk of developing such illnesses. Specialty, academic year, age and marital status didn’t have a significant impact. The data did not show linear regression between the ASOC score and health specialty.
Conclusion: We concluded that college students of all different specialties and demographics suffer from mental health disorders and have to deal with high levels of stress, anxiety and depression.
DOI: 10.37421/2572-0791.2022.08.14
DOI: 10.37421/2572-0791.2022.08.12
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DOI: 10.37421/2572-0791.2022.08.13
DOI: 10.37421/2572-0791.2022.8.31
There is evidence to back up the idea that some antidepressants can lower levels of various cytokines in both humans and animals, and more recently, it has been revealed that some antidepressant have antiviral effect against SARS-CoV-2. The purpose of this narrative review is to assess the potential value of antidepressants in the management of COVID-19 infection as well as the potential advantages and disadvantages of antidepressant therapy for COVID-19 infections and mental problems. An analysis of the recent literature was done to determine the place of antidepressant drugs in the care of COVID-19 patients. Additionally, two phase II studies investigating fluvoxamine that were published and showed promising results against a placebo for clinical deterioration and hospitalisation rate. The first stages of seven ongoing clinical trials are examining fluvoxamine, fluoxetine and tramadol. The results from several observational studies, two phase II clinical testing, and the aggregate of the antiviral and anti-inflammatory laboratory development form the basis for ongoing clinical trials trying to investigate the potential use of antidepressants for COVID-19 infection in humans, despite the amount of evidence is limited.
DOI: 10.37421/2572-0791.2022.8.33
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DOI: 10.37421/2572-0791.2021.7.006
DOI: 10.37421/2572-0791.2021.7.007
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DOI: 10.37421/2572-0791.2021.7.009
DOI: 10.37421/2572-0791.2021.7.010
Sahar Raza and Samia Amin*
DOI: 10.4172/2572-0791.1000134.08.15
Pregnancy and the postpartum period are known to have increased vulnerability to psychological disorders. This article aimed to reveal the psychological impacts of pregnancy in the current COVID-19 pandemic. PubMed, EMBASE, PsycINFO, and CINAHL databases were searched to include studies between 1 January 2000 and 31 December 2021. Two reviewers screened all studies and narrative data synthesis was conducted. This review analysed four studies, which involved a total of 1,742 pregnant mothers with diverse locations globally. Reports suggest that COVID-19 impacted differently on pregnant mothers, which in turn leads to distinctive psychological outcomes such as depression, anxiety, and thoughts of self-harm. Data for all studies were collected from early 2020; such preliminary results highlight the need for further research into the impacts of such maternal psychological consequences on childcare in the context of COVID-19. Furthermore, efforts are continually needed to reduce barriers to mental health services, including addressing the stigma of depression or anxiety among pregnant mothers. Filling such knowledge and research gap will foster the development of guidelines and interventions to better support pregnant mothers who experience the difficulties of the COVID-19 pandemic.
DOI: 10.4172/2572-0791.1000134.08.17
DOI: 10.37421/2572-0791.2022.08.18
DOI: 10.37421/2572-0791.2022.08.16
DOI: 10.4172/2572-0791.1000134.08.15
DOI: 10.37421/2572-0791.2022.8.26
DOI: 10.37421/2572-0791.2022.8.24
DOI: 10.37421/2572-0791.2022.8.25
The point of the current review was to look at side effect classes of significant burdensome problem (MDD), delayed sadness jumble and posttraumatic stress jumble in an example of self destruction dispossessed people, while representing misfortune related qualities. An idle class examination was directed to distinguish classes of the self destruction dispossessed, sharing side effect profiles, in a German self-destruction deprived example (N=159). Our examinations uncovered three fundamental classes: a strong class (16%), a class with high underwriting likelihood for PGD side effects (half), and a class with high support likelihood for joined PGD/PTSD side effects (34%). Drawn out pain and meddlesome side effects arose across all classes, while MDD showed low underwriting likelihood. Our outcomes demonstrate a relationship between class enrollment and time elapsed since the misfortune; be that as it may, this applies just to the correlation between the PGD and the strong class, and not for the PGD/PTSD class. Our outcomes might give data about the consistency of side effect groups following self-destruction deprivation. The discoveries likewise address a critical stage towards fitting medicines in view of the necessities of important self-destruction deprived subgroups through a side effect level methodology. Time elapsed since misfortune could make sense of contrasts between side effect groups.
DOI: 10.37421/2572-0791.2022.8.27
A huge extent of teenagers experiencing significant burdensome issue (MDD) are probably going to have a co-dreary behavioral condition (PD). Transient psychoanalytic psychotherapy (STPP) was viewed as one treatment of decision for youths experiencing MDD. Foundation: The first exploratory investigation of transaction work-in quite a while (FEST-IT) showed the usefulness of transaction work in STPP with youths experiencing MDD. The handiness of STPP might be improved by investigating potential arbitrators. Strategies: Depressed young people (N=69), matured 16- 18 years, were determined to have the organized meeting for DSM-IV PDs and randomized to 28 weeks of STPP regardless of transaction work. A blended straight model was applied. The mediator impact was explored by a three-way communication including "time", "treatment gathering" and "number of PD standards". Results: A little however huge mediator impact was found for group B character pathology. Patients with a larger number of group B PD rules at gauge improved as long as one-year post-treatment where specialists urged patients to investigate the patientspecialist relationship in the present time and place. End: When treated with psychoanalytic psychotherapy for MDD, youths with group B PD side effects appear to benefit more from transaction work than teenagers without such pathology.
DOI: 10.37421/2572-0791.2022.8.28
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DOI: 10.37421/2375-2572-0791.8.34
Understanding the long-term impacts of marijuana usage is essential as adolescent marijuana use has been rising. According to earlier studies, marijuana use during adolescence raises the likelihood of mental disorders such schizophrenia, depression, and anxiety. The peptide ghrelin, which is largely generated in the gut, has a significant role in feeding behaviour. Recent research has demonstrated that ghrelin and the growth hormone secretagogue receptor, which is its receptor, are critical mediators of stress, anxiety, and depressive-like behaviours in animal models. Here, we examined the effects of persistent administration on anxiety-like behaviours in knockout mice and their wild-type littermates during late adolescence. Continuous exposure during late adolescence, according to our findings.
DOI: 10.37421/2375-2572-0791.8.35
Pregnancy is typically regarded as a happy experience, but it also intensifies a woman's emotional and psychological state. Worldwide, some women experience mental illnesses, particularly in developing countries. There is proof that sadness, anxiety, and stress during pregnancy are very common in Nigeria. In order to determine the extent and contributing variables of depression, anxiety, and stress among pregnant women in Port Harcourt, Nigeria Between September and November 2022, two tertiary hospitals in Port Harcourt city undertook a facility-based crosssectional survey utilising the Depression Anxiety and Stress was used to conduct univariate, bivariate, and multivariate analyses. The statistical significance was determined at p 0.05 and the proportional odds model was applied.
DOI: 10.37421/2375-2572-0791.8.36
DOI: 10.37421/2375-2572-0791.8.37
DOI: 10.37421/2375-2572-0791.8.38
DOI: 10.37421/2572-0791.2023.9.44
Depression is a serious mental illness that affects millions of people worldwide. According to the World Health Organization, over 264 million people worldwide suffer from depression, making it one of the leading causes of disability worldwide. Depression is a complex disorder that can be caused by a variety of factors, including genetics, brain chemistry, and life events. Clinical Depression as Major Depressive Disorder (MDD) is a mental illness that affects millions of people worldwide. According to the World Health Organization, depression is one of the leading causes of disability worldwide, and it is estimated that over 264 million people globally suffer from depression. The exact causes of clinical depression are not fully understood, but it is believed to be a combination of genetic, biological, environmental, and psychological factors. Some of the risk factors that increase the likelihood of developing depression include.
DOI: 10.37421/2572-0791.2023.9.42
DOI: 10.37421/2572-0791.2023.9.53
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Repetitive transcranial magnetic stimulation has been recognized as a promising non-invasive therapeutic tool for treating mood disorders such as bipolar and unipolar disorders. However, response to rTMS treatment can be highly variable between individuals, and little is known about the predictors of clinical response in these populations. In this article, we will discuss recent research findings regarding the differential predictors of clinical response after repeated transcranial magnetic stimulation in bipolar and unipolar disorders.
DOI: 10.37421/2572-0791.2023.9.46
DOI: 10.37421/2572-0791.2023.9.48
DOI: 10.37421/2572-0791.2023.9.49
Alcohol and opioid addiction is a significant public health issue that affects millions of people globally. The problem is compounded when mental health issues are involved. Mental health disorders such as depression, anxiety, and Post-Traumatic Stress Disorder (PTSD) can trigger addiction, and addiction can lead to mental health issues. This vicious cycle makes it difficult for individuals to break free from addiction and seek treatment.
DOI: 10.37421/2572-0791.2023.9.50
Mental health disorders among adolescents have become a significant problem globally. The World Health Organization (WHO) has estimated that globally, 10-20% of children and adolescents suffer from mental disorders. Adolescents with mental health disorders, including anxiety, depression, and other related conditions, often face significant challenges in their daily lives, including academic difficulties, relationship issues, and social isolation. In recent years, animal-assisted therapy (AAT) has gained popularity as a non-invasive and non-pharmacological intervention to support adolescents with mental health disorders. This article discusses the effectiveness of AAT in supporting adolescents with mental health disorders, creating a human-animal bond, and potential therapeutic outcomes.
DOI: 10.37421/2572-0791.2023.9.51
DOI: 10.37421/2572-0791.2023.9.52
DOI: 10.37421/2572-0791.2023.9.39
Puerperium is a time of considerable vulnerability for women and is accompanied by significant physical and psychological changes. The term "maternity blues" sometimes known as "baby blues," "postnatal blues," or "post-partum blues," refers to a state of low mood and mild, temporary, self-limiting depression symptoms that might start to appear in the days immediately following childbirth. However, due to the lack of a common definition and reliable diagnostic techniques, it is challenging to correctly identify this illness. Regarding the prevalence of there is considerable documented global heterogeneity. Studies reported an overall prevalence, with variations between cultures and regions ranging from is a known risk factor for developing postpartum mood disorders that are more severe, such postpartum depression and postpartum psychosis.
DOI: 10.37421/2572-0791.2023.9.40
Postpartum depression is a postpartum symptom in black women. Despite the significant proportion of Black women who have symptoms, postpartum depression is rarely accurately diagnosed and few obtain mental health care. Although the causes of this difference are unknown, they are probably complex. Black women are more vulnerable to sexism, racism, and classism due to the confluence of their gender, race, racial identity, and class, which puts them under more mental and physical strain and may raise their likelihood of developing certain diseases. The severity of May also affect a woman's capacity to care for herself and her unborn child and return to her regular activities before giving birth. Previous research has looked at the connection between Black racial identification and or maternal. Previous research has looked at the connection between Black racial identification and maternal functioning on an individual basis, but it hasn't taken into account how they interact to affect maternal functioning. As a framework for our selection and analysis of, social and racial factors that may affect Black women's functional status after childbirth, we use the triangulation of concepts from the Nigrescence.
DOI: 10.37421/2572-0791.2023.9.41
DOI: 10.37421/2572-0791.2023.9.43
DOI: 10.37421/2572-0791.2023.9.54
Anorexia nervosa is a serious eating disorder that affects both men and women. It is characterized by a distorted body image and an intense fear of gaining weight. A can lead to severe physical and psychological consequences, including hormonal imbalances. In recent years, hair analysis has emerged as a valuable tool for measuring hormones over a longer period than blood or urine samples. This article will explore the characterization of menstrual steroid growth hormones in patients with a using hair analysis.
DOI: 10.37421/2572-0791.2023.9.59
Depression is a complex and debilitating mental health disorder that affects millions of people worldwide. It is characterized by persistent feelings of sadness, loss of interest or pleasure, changes in appetite and sleep patterns, difficulty concentrating, and a lack of energy. While the exact cause of depression remains elusive, extensive research has been conducted to explore its neurobiological basis. Clinical studies have provided valuable insights into the neurochemical, structural, and functional alterations in the brain associated with depression. This article aims to delve into the understanding of the neurobiological basis of depression by examining key findings from clinical studies. One prominent hypothesis regarding the neurobiological basis of depression focuses on the role of neurotransmitters. Neurotransmitters are chemical messengers that facilitate communication between neurons in the brain. Clinical studies have consistently demonstrated alterations in the levels of certain neurotransmitters in individuals with depression.
DOI: 10.37421/2572-0791.2023.9.62
DOI: 10.37421/2572-0791.2023.9.55
Postpartum depression is a postpartum symptom in black women. Despite the significant proportion of Black women who have symptoms, postpartum depression is rarely accurately diagnosed and few obtain mental health care. Although the causes of this difference are unknown, they are probably complex. Black women are more vulnerable to sexism, racism, and classism due to the confluence of their gender, race, racial identity, and class, which puts them under more mental and physical strain and may raise their likelihood of developing certain diseases. The severity of May also affect a woman's capacity to care for herself and her unborn child and return to her regular activities before giving birth. Previous research has looked at the connection between Black racial identification and or maternal. Previous research has looked at the connection between Black racial identification and maternal functioning on an individual basis, but it hasn't taken into account how they interact to affect maternal functioning. As a framework for our selection and analysis of, social and racial factors that may affect Black women's functional status after childbirth, we use the triangulation of concepts from the Nigrescence.
DOI: 10.37421/2572-0791.2023.9.56
DOI: 10.37421/2572-0791.2023.9.57
DOI: 10.37421/2572-0791.2023.9.58
DOI: 10.37421/2572-0791.2023.9.60
Depression Stress is a well-known risk factor for depression, and emerging research suggests that the relationship between stress and depression may be mediated by inflammation. Chronic stress can lead to increased production of pro-inflammatory cytokines, and in turn, chronic inflammation can sensitize the stress response system, perpetuating a vicious cycle. This bidirectional relationship between stress, inflammation, and depression highlights the complex interplay between these factors. The growing understanding of the role of inflammation in depression has significant implications for clinical interventions. Here are some potential strategies that target inflammation for the management of depression.
DOI: 10.37421/2572-0791.2023.9.61
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DOI: 10.37421/2572-0791.2023.9.72
DOI: 10.37421/2572-0791.2023.9.64
The field of geriatric psychiatry poses unique challenges, one of which is the co-occurrence of panic attacks in elderly patients with depression. Panic attacks are sudden, intense surges of fear and anxiety, often accompanied by physical symptoms such as heart palpitations, sweating, trembling, and shortness of breath. Depression, on the other hand, is characterized by persistent low mood, lack of interest or pleasure, and a range of cognitive and physical symptoms. When these two conditions intersect, clinicians face intricate diagnostic, treatment, and management dilemmas. This paper delves into the complexities of addressing panic attacks in elderly patients with depression, exploring diagnostic intricacies, treatment considerations, and the broader biopsychosocial context.
DOI: 10.37421/2572-0791.2023.9.65
Postpartum depression is a postpartum symptom in black women. Despite the significant proportion of Black women who have symptoms, postpartum depression is rarely accurately diagnosed and few obtain mental health care. Although the causes of this difference are unknown, they are probably complex. Black women are more vulnerable to sexism, racism, and classism due to the confluence of their gender, race, racial identity, and class, which puts them under more mental and physical strain and may raise their likelihood of developing certain diseases. The severity of May also affect a woman's capacity to care for herself and her unborn child and return to her regular activities before giving birth. Previous research has looked at the connection between Black racial identification and or maternal. Previous research has looked at the connection between Black racial identification and maternal functioning on an individual basis, but it hasn't taken into account how they interact to affect maternal functioning. As a framework for our selection and analysis of, social and racial factors that may affect Black women's functional status after childbirth, we use the triangulation of concepts from the Nigrescence.
DOI: 10.37421/2572-0791.2023.9.66
DOI: 10.37421/2572-0791.2023.9.67
DOI: 10.37421/2572-0791.2023.9.68
DOI: 10.37421/2572-0791.2023.9.69
As the world's population ages, the understanding of mental health concerns among the elderly becomes increasingly crucial. Geriatric depression is a multifaceted issue that often presents with a range of symptoms, including panic attacks. These panic attacks can be intricate to diagnose due to the overlapping symptomatology with other disorders, further complicating the assessment and treatment process. This essay delves into the intricacies of panic attacks within the context of geriatric depression, highlighting the challenges in diagnosis, potential causes, and effective management strategies. Geriatric depression, also known as late-life depression or elderly depression is a prevalent mental health issue among older adults. It is characterized by persistent feelings of sadness, loss of interest in previously enjoyed activities, changes in appetite or weight, sleep disturbances, fatigue, difficulty concentrating, and even thoughts of death or suicide. These symptoms often overlap with those of other medical and psychiatric conditions, leading to diagnostic challenges.
DOI: 10.37421/2572-0791.2023.9.70
As the global population continues to age, understanding and addressing mental health issues among the elderly population has become an imperative concern. Among the various mental health challenges faced by older adults, two significant ones are elderly depression and panic attacks. These conditions present diagnostic and therapeutic complexities due to overlapping symptoms, physiological changes, and the need for specialized care. This essay delves into the diagnostic challenges, therapeutic interventions, and the conundrums surrounding elderly depression and panic attacks. Distinguishing between elderly depression and panic attacks is often intricate due to overlapping symptoms. Both conditions can manifest with somatic complaints, such as fatigue, sleep disturbances, and changes in appetite. The shared symptoms can lead to misdiagnosis, delayed intervention, or the misattribution of one condition to another.
DOI: 10.37421/2572-0791.2023.9.71
DOI: 10.37421/2572-0791.2023.9.73
DOI: 10.37421/2572-0791.2024.10.101
In the intricate labyrinth of mental health, depression often stands as a formidable adversary, casting its shadow over millions of lives worldwide. It's a complex condition that doesn't discriminate, affecting individuals regardless of age, gender, or background. Fortunately, within this labyrinth exists pathways to healing, where therapy serves as a guiding light, offering hope and resilience to those grappling with depression. Before delving into therapeutic interventions, it's crucial to grasp the intricate nuances of depression. Depression isn't merely feeling sad or blue; it's a multifaceted mental health disorder characterized by persistent feelings of sadness, hopelessness and disinterest in activities once found pleasurable. It can manifest in various forms, ranging from major depressive disorder to seasonal affective disorder, each with its unique set of symptoms and challenges. Therapy serves as a cornerstone in the treatment of depression, offering a safe space for individuals to explore their thoughts, emotions and behaviors.
Sorut Wongsuttitum, Boonyapa Pokasem* and Chaweerat Chernchomkul
DOI: 10.37421/2572-0791.2024.10.94
Depression is a barrier to human workforce. However, the lack of major policies and guidelines for depression disorder in Thailand hinders healthcare workers from addressing this issue. Therefore, this research examines ways to develop depressive disorders in laborers. This study used a qualitative approach to examine the context of depression management in labor. The results of this study presented factors related to depression management from individual to organizational contexts. This finding suggests that stakeholders should attend to the first step of depression prevention outside healthcare services.
DOI: 10.37421/2572-0791.2024.10.95
Bringing a new life into the world is often depicted as one of life's most joyous occasions. However, for many new mothers, the period following childbirth can be accompanied by a range of intense emotions, including sadness, anxiety and despair. While some degree of mood fluctuation is common after giving birth, for some women, these feelings can escalate into a serious condition known as Postpartum Depression (PPD). Postpartum depression is a form of clinical depression that occurs after childbirth, affecting approximately 1 in 10 women according to the American Psychological Association. It is important to distinguish between the "baby blues," a milder and more common condition characterized by mood swings, tearfulness and fatigue and PPD, which is more severe and longer-lasting. The exact causes of postpartum depression are not fully understood, but a combination of physical, emotional and lifestyle factors is believed to contribute to its development. Hormonal fluctuations, particularly a rapid decrease in estrogen and progesterone levels following childbirth, can play a significant role in triggering PPD. Additionally, sleep deprivation, physical discomfort from childbirth and the stress of caring for a newborn can exacerbate feelings of depression and anxiety.
DOI: 10.37421/2572-0791.2024.10.96
DOI: 10.37421/2572-0791.2024.10.97
DOI: 10.37421/2572-0791.2024.10.98
DOI: 10.37421/2572-0791.2024.10.99
Depression, a multifaceted mental health condition, manifests in various forms, affecting individuals in unique ways. Among its classifications, endogenous depression stands as a distinct entity, characterized by a complex interplay of biological, psychological and environmental factors. Unlike reactive depression triggered by external events, endogenous depression arises from internal dysregulations within the brain, presenting a unique challenge in diagnosis and treatment. Endogenous depression, also known as biological or clinical depression, stems primarily from biological factors rather than external stressors. Unlike situational depression, which often has identifiable triggers, endogenous depression emerges seemingly without external cause. It encompasses a profound sense of despair, persistent low mood, anhedonia (loss of interest or pleasure) and disturbances in sleep, appetite and energy levels. Individuals afflicted by endogenous depression may find it challenging to pinpoint the source of their anguish, amplifying feelings of confusion and hopelessness.
DOI: 10.37421/2572-0791.2024.10.100
Neurotic depression, often referred to as dysthymia or persistent depressive disorder, is a mental health condition characterized by a persistent low mood, feelings of hopelessness and a lack of interest or pleasure in most activities. Unlike major depression, which can manifest in episodic episodes, neurotic depression is chronic and can last for years if left untreated. However, despite its persistence, neurotic depression is treatable and there are numerous strategies individuals can employ to navigate their journey towards healing. Neurotic depression is a complex condition that can have various causes, including genetic predispositions, brain chemistry imbalances and environmental factors such as trauma or chronic stress. Individuals with neurotic depression often experience a constant sense of sadness or emptiness, even during periods of relative stability. They may also struggle with low self-esteem, feelings of guilt or worthlessness and difficulty concentrating.
DOI: 10.37421/2572-0791.2024.10.102
DOI: 10.37421/2572-0791.2024.10.103
Clinical Depression received 89 citations as per Google Scholar report
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