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Due date of the submission: 19 June 2017
Development of an effective HIV-1 vaccine candidate is one of the most challenging tasks in this specific research field. There is no conclusion so far whether both T cells and/or B cells would contribute significantly to the HIV-1 protection efficacy. It is dependent on the vaccine platforms tested in non-human primate models or the clinical setting utilized. The hallmark towards deeper understanding of the failure and the pathway to the success comes from central immunology - activation of the immune responses in multi-dimensional levels. Therefore, this special issue on "HIV-1 vaccine immunology" will cover the broad picture in the past and current knowledge of the different HIV-1 vaccine platforms. This will include the HIV-1 immunogen design (e.g., atomic structure), adjuvant formulation, viral vectors and immunization routes, combination of HAART and other therapeutics. The comprehensive picture of the current achievement in HIV-1 vaccine immunology will provide essential grounds for the future understanding and development of an effective HIV-1 vaccine candidate. We specifically invite you as an expert in the HIV-1 vaccine immunology to submit an original research, review and opinion article which may contribute for better understanding and paving the direction in the HIV-1 vaccine immunology.