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Studies indicate that epigenetic modification promotes susceptibility among human due to altered gene expressions. The epigenetic mechanisms used by the cells to control the transposable elements are well comprehended in the studies. Silencing mechanism of gene throughout the course of evolution is a key aspect of gene regulation and chromosome biology. The study of these epigenetic regulations has provided new possibilities for diagnostics, prognostics and therapy of many diseases including cancer, ageing and many other genetic diseases.