Figure 2: Proteostasis disruption leads to Aging. Oxidative stress impairs the proteins folding post-transnationally or during the translation. Unfolded or misfolded proteins are generally processed by two pathways. In first way, they are either undergoes proteins degradation by various pathways in cluding lysosomal/cheparon –mediated autophagy and ubiquitin – proteosomal degradation. Otherwise, they are refolded by folding chaperons like heat shock proteins. If the protein fails two undergo either of process, it tries to aggregate in haphazard manner, leading to proteotoxicity and thus, aging.