Figure 1: Conservation of domain structure and primary sequence of Cbl family proteins through evolution. Structure and domains of Cbl proteins from various indicated species are shown. Amino acid (AA) sequence identity within the indicated domains relative to human Cbl are shown in the table to the right. The protein designations are indicated on left. TKB – tyrosine kinase binding; 4H – 4-helical bundle; EF – calcium-binding EF hand, SH2 – phosphotyrosine-binding Src Homology 2 domain; LHR – linker helical region; RF – RING finger domain; P – proline-rich region; UBA – ubiquitin-associating domain.