Database ID IVIg
(RFU)
CV
(%)
Neg (RFU Fold Description
BC017865.1 10582 3 267 39,6 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (FCGR3A) (*)
NM_024826.1 7057 4 289 24,5 Microtubule-associated protein 9 (*)
BC064612.1 3540 1 254 14,0 Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 (MLLT6) (*)
NM_023930.1 5321 3 409 13,0 Potassium channel tetramerisation domain containing 14 (KCTD14)
NM_004987.3 3450 1 267 12,9 LIM and senescent cell antigen-like-containing domain protein 1
BC001553.1 2386 3 241 9,9 Chromatin modifying protein 2B (CHMP2B)
BC022893.1 6805 7 737 9,2 Potassium channel tetramerisation domain containing 6 (KCTD6)
BC036723.1 2990 1 348 8,6 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) (FCGR3A)
BC000393.1 7147 1 838 8,5 Family with sequence similarity 127, member B (FAM127B)
NM_018184.1 3304 18 403 8,2 ADP-ribosylation factor-like 8B (ARL8B) (*)
NM_201403.1 4039 9 557 7,3 MOB1, Mps One Binder kinase activator-like 2C (yeast) (MOBKL2C),
BC017202.2 3812 0 549 6,9 Isovaleryl-CoA dehydrogenase, mitochondrial (*)
NM_021630.4 4018 0 607 6,6 PDZ and LIM domain protein 2
NM_201613.1 4095 6 626 6,5 IKK interacting protein (IKIP), transcript variant 3.1
BC022893.1 6019 10 936 6,4 Potassium channel tetramerisation domain containing 6 (KCTD6)
BC030253.1 2376 4 387 6,1 Glutathione S-transferase M3 (brain) (GSTM3)
BC007346.2 5822 6 955 6,1 Uncharacterized protein C16orf14
BC048099.1 2197 7 364 6,0 Zinc finger and SCAN domain containing 1 (ZSCAN1) (*)
NM_003302.1 2428 4 411 5,9 Thyroid hormone receptor interactor 6 (TRIP6)
NM_005440.3 4311 2 752 5,7 Rho family GTPase 2 (RND2)
NM_001004286.1 5142 2 913 5,6 DNA fragmentation factor subunit beta
NM_012094.3 2445 1 443 5,5 Peroxiredoxin 5 (PRDX5), nuclear gene encoding mitochondrial protein,
NM_012395.2 2179 12 404 5,4 PFTAIRE protein kinase 1 (PFTK1)
NM_003130.1 2072 2 384 5,4 Sorcin (SRI), transcript variant 1
NM_207350.1 2704 16 520 5,2 Similar to FRG1 protein (FSHD region gene 1 protein) (MGC72104)
BC003065.1 3476 9 672 5,2 Cell division protein kinase 2 (*)
BC033817.1 3722 8 738 5,0 PC4 and SFRS1 interacting protein 1 (PSIP1)
NM_014288.2 3104 3 621 5,0 Centromere protein R
NM_023940.1 3078 4 619 5,0 RAS-like, family 11, member B (RASL11B)
NM_004092.2 3823 2 772 5,0 Enoyl-CoA hydratase, mitochondrial
BC014385.1 2153 21 436 4,9 Integrin beta 3 binding protein (beta3-endonexin) (ITGB3BP)
NM_016848.2 2988 1 630 4,7 SHC-transforming protein 3
NM_197962.1 2813 2 618 4,6 Glutaredoxin 2 (GLRX2), transcript variant 2
NM_002927.3 2162 18 478 4,5 Regulator of G-protein signaling 13 (RGS13), transcript variant 1
BC009779.1 2537 2 563 4,5 Outer dense fiber of sperm tails 2-like (ODF2L)
NM_016816.1 3497 1 781 4,5 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1), transcript variant 1
NM_005034.2 2009 3 478 4,2 Polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa (POLR2K)
NM_017451.1 3392 7 819 4,1 BAI1-associated protein 2 (BAIAP2), transcript variant 2
NM_012289.2 3919 17 994 3,9 Kelch-like ECH-associated protein 1
BC003549.1 3466 7 889 3,9 Enoyl Coenzyme A hydratase domain containing 1 (ECHDC1)
BC021189.2 2580 4 666 3,9 cDNA clone IMAGE:4829245
BC002914.1 2787 7 744 3,7 WAS/WASL-interacting protein family member 1
BC030592.2 2890 9 795 3,6 HIV-1 Rev binding protein (HRB)
BC009873.1 2144 11 592 3,6 cDNA clone IMAGE:3946787, partial cds
NM_023938.4 2013 5 566 3,6 Specifically androgen-regulated gene protein
NM_014583.2 3095 3 915 3,4 LIM and cysteine-rich domains 1 (LMCD1)
NM_203425.1 3139 0 930 3,4 Chromosome 17 open reading frame 82 (C17orf82)
NM_002904.4 2140 11 637 3,4 RD RNA binding protein (RDBP)
BC030950.1 2343 1 721 3,3 Small nuclear protein PRAC
BC035582.1 2857 1 886 3,2 Tripartite motif-containing protein 22
BC009967.1 2091 8 682 3,1 N-terminal kinase-like protein
BC004259.1 2687 2 885 3,0 Chromosome 14 open reading frame 140 (C14orf140)
NM_016364.2 2719 8 897 3,0 Dual specificity phosphatase 13 (DUSP13), transcript variant 6
NM_144594.1 2135 3 726 2,9 Family with sequence similarity 112, member B (FAM112B)
NM_016096.1 2132 5 726 2,9 Zinc finger protein 706 (ZNF706), transcript variant 2
NM_144736.3 2688 1 919 2,9 Protein midA homolog, mitochondrial
NM_003161.1 2717 7 955 2,8 Ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1)
BC009894.2 2465 3 869 2,8 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2)
BC056911.1 2632 4 960 2,7 Dual specificity phosphatase 15 (DUSP15)
NM_015698.2 2036 1 747 2,7 G patch domain and KOW motifs (GPKOW)
BC034401.1 2132 0 787 2,7 cDNA clone IMAGE:5172086, partial cds
NM_005678.3 2516 6 973 2,6 SNRPN upstream reading frame (SNURF), transcript variant 1
PV3665 2237 1 892 2,5 Casein kinase 1, delta (CSNK1D), transcript variant 1
NM_006479.2 2029 7 821 2,5 RAD51 associated protein 1 (RAD51AP1)
NM_207356.1 2152 7 871 2,5 Chromosome 1 open reading frame 174 (C1orf174)
BC051000.1 2024 2 838 2,4 T-cell leukemia/lymphoma 1B (TCL1B)
BC033230.1 2189 5 943 2,3 Zinc finger protein 808 (ZNF808)
1.IVIg interactions were analyzed using 1.0 µg/mL. Data include IVIg signal (threshold >2000) corresponding to background subtracted pixel intensity value (RFU), the CV associated with the duplicate spots for each protein and the fold increase between IVIg signal versus negative signal (Neg) used for the corresponding protein in the negative control assay.
2.(*) Indicated significant interaction whith IVIg at 0.1μg/ml (using a Signal threshold greater than 1000 RFU).
Table 1: Therapeutic immunoglobulin pattern of interaction with human proteins.