CLASS SUBCLASS EXAMPLES REFERENCE Class I Lantibiotics < 5 KDa Ia: Cationic linear peptides. Ib: Globular peptides with no net charge or charge no. Nisin Epidermin Lacticin 3147 Mersacidin [154] [123] [156] [95]   Class II Bacteriocins heat-stableunmodified < 10 kDa IIa: Anti-Listeria bacteriocins similar to pediocin Pediocin PA-1 Enterocin A   IIb: Heterodimeric Bacteriocins. Pediocin PA-1 Enterocin A   IIc: Sec-dependent Bacteriocins. Lactacin F Lactococcin G [11] IId: Bacteriocins without leader peptide. Bacteriocin 31 Enterocin P [52] IIe: Cyclical Bacteriocins. EJ97 Enterocin L50 [37,41,76] IIf: Nonclustered Bacteriocins. AS-48     Circularin A Gassericin A [11]   Lactococcin A Enterocin B     Class III Largeheat-labileproteins (Bacteriolisins) * > 30 Kda Helveticin J Enterolisin A [54]

Table 1: Classification of bacteriocins based on classifications proposed by Diep et al. [23,32,53] and Cotter et al. [58,68]. Class IV (non-protein motifs bacteriocins) is not included because it has not demonstrated the existence of members of this class. * It is suggested that this class is not considered as bacteriocins.