| Atypical |
CYP1A2 |
CYP2D6 |
CYP3A4 |
| Amisulpride |
|
|
|
| Aripiprazole |
|
Substrate |
Substrate |
| Asenapine |
Substrate |
Inhibitor (weak) |
|
| Clotiapine |
|
|
|
| Clozapine |
Substrate |
Substrate |
Substrate |
| Olanzapine |
Substrate |
Substrate |
|
| Paliperidone |
|
|
|
| Quetiapine |
|
Substrate |
Substrate |
| Risperidone |
|
Substrate |
Substrate |
| Sulpiride |
|
|
|
| Tiapride |
|
|
|
| Ziprasidone |
|
|
Substrate |
| Typical |
CYP1A2 |
CYP2D6 |
CYP3A4 |
| Chlorpromazine |
Substrate |
Inhibitor |
|
| Fluphenazine |
Substrate |
Inhibitor |
|
| Haloperidol |
Substrate |
Inhibitor (potent) |
Substrate |
| Levomepromazine |
|
Inhibitor |
|
| Perphenazine |
|
Inhibitor |
|
| Pimozide |
Substrate |
Inhibitor (potent) |
Substrate |
| Zuclopenthixol |
|
Substrate |
|
Green color means that the drug is not metabolized by CYP-related metabolism or the metabolism is not significant clinically. Yellow means that the drug is a substrate of the isoenzyme and red is related to the inhibitory potential of the drug.
Data based on the respective drug labels and the following references: [7,34,36,37] |
|