Substrates Inhibitors Inducers Antipsychotics: Aripiprazole Clozapine Haloperidol Risperidone Quetiapine Sertindole Ziprasidone Pimozide     Antidepressants: Tricyclics Citalopram Escitalopram Mirtazapine Venlafaxine Desvenlafaxine Fluoxetine Fluvoxamine Paroxetine Sertraline   Others: Benzodiazepines Caffeine Calcium channel antagonists Cocaine Statins Astemizole Cisapride Cyclosporine Sirolimus Tacrolimus Donepezil Ethinyl estradiol Levonorgestrel Quinidine Tamoxifen Terfenadine TramadolFentanyl Omeprazole Lansoprazole Warfarin Amiodarone Atazanavir Boceprevir Ciprofloxacin Clarithromycin Cyclosporine Darunavir Erythromycin Gingko-biloba Grapefruit juice Indinavir Itraconazole Ketoconazole Lopinavir Methadone Nefazodone Ritonavir Telaprevir Troleandomycin Valproic acid Barbiturates Carbamazepine Dexamethasone Efavirenz Etravirine Glucocorticoids Melatonin Nevirapine Phenytoin Prednisone Rifampicin Ritonavir St John’s wort Topiramate

Table 5: Main substrates and clinically relevant inhibitors, and inducers of human CYP3A4.