Type of pathology Molecule(s) References Ischemia/reperfusion injury glutamate, aspartate, glycine GABA lactate pyruvate glucose adenosine myoglobin (cardiac ischemia) [81, 83, 96, 98, 100, 101] Subarachnoid hemorrhage glutamate glutamine histidine glycine lactate IL-6 [89,90, 102,103] Traumatic brain injury tau, amyloid beta glucose [88, 104] Parkinson’s disease dopamine 3-methoxytyramine 3,4-dihydroxyphenylacetic acid serotonin HVA GABA glutamate cathecholamines [86, 94, 95, 105] Alzheimer’s disease acetylcholine apolipoporotein E beta-amyloid protein amyloid beta oligomers [69, 92, 93] Epilepsy glutamate GABA adenosine acetylcholine [106, 107,108] Psychiatricdisorders (schizophrenia) serotonin dopamine GABA [109, 110] Inflammation interleukin-1 interleukin-8 interleukin-10 interleukin-6 TNF-alpha VEGF NGF [99, 111, 112] Enterocholitis glucose lactate pyruvate glycerol [49] Diabetes glucose lactate pyruvate glycerol urea [113, 114] Pain substance-P beta endorphin pyruvate lactate cortisol glutamate serotonin norepinephrine dopamine leukotriene B4 PGE2 [115-117] Smoking dopamine [118-120] Drug abuse dopamine glutamate [121-123]

Table 3: Target molecules of microdialysis in neurotransmitter and biomarker studies.