Figure 2: Shows the tissue reactions as well as the integration behavior of the Mucoderm® matrix (MD) at days 3 (A and B), 10 (C and D) and 15 (E and F) after implantation in subcutaneous connective tissue (CT) of the CD-1-mice. On days 3, 10 and 15 after implantation (A, C and E) a thin wall of mononuclear cells (black arrow heads) was observed at the surfaces of the membranes (MD), while a comparbly low number of cells was found within the body of the matrix (green arrow heads) (CT=Connective Tissue) (A: H&E-stain, C: Movat Pentachrome-stain, E: MovatPentachrome -stain; 400x magnifications; scale bars = 10 μm). Within this time frame the matrix remained stable within the subcutaneous connective tissue (CT) and no signs of tissue ingrowth were observable (B, D and F). The described fatty tissue-like islands (black arrows) as wells as the vessel skeletons (blue arrow heads) were invaded by single mononuclear cells at these time points (B: H&E-stain; D: Movat Pentachromestain; F: Sirius-Stain, 100x magnifications, scale bars=100 μm).