Figure 3: Upper panel: Effect of pSS IgG anti M3 on NOS activity in salivary gland. Submandibular gland were incubated with increasing concentrations of pSS IgG anti M3 alone (●) or in the presence of 1x10-5 M (S) Methylisothioures (S-Methy-U) (♦), 5x10-6 M L-NIO dehydrochloride (L-NIO) (▲) or 5x10-6 M N-Propyl-L-arginine hydrochloride (N-PL) (▼). *P<0.0001 versus pSS IgG anti M3. Values are mean ± SEM of five experiments performed in duplicate. Lower panel: Table insert in Figure showed the effect of normal IgG anti M3 (n IgG anti M3) alone or in the presence of different NOS isoforms inhibitors taken as control values.