SNP

Gene

Risk allele

ARIC

MESA

Pooledb

OR (95% CI)

P-value

OR (95% CI)

p-value

OR

P-value

rs10923931

NOTCH2
ADAM30

T

1.43 (1.30-1.57)

2.1×10^-14

1.35 (1.16-1.57)

1.32×10^-4

1.41 (1.30-1.52)

1.54×10^-17

rs780094

GCKR
TMEM195

C

1.33 (1.22-1.44)

2.5×10^-11

1.30 (1.14-1.47)

5.40×10^-5

1.32 (1.23-1.41)

6.63×10^-15

rs1801282

PPARG

C

1.53 (1.32-1.77)

1.48×10^-8

1.53 (1.19-1.96)

9.66×10^-4

1.53 (1.35-1.74)

5.56×10^-11

rs1470579

IGF2BP2

G

1.50 (1.39-1.61)

3.27×10^-28

1.24 (1.11-1.38)

1.95×10^-4

1.37 (1.13-1.65)

1.2×10^-3

rs10946398

CDKAL1

G

1.34 (1.24-1.44)

7.43×10^-14

1.44 (1.28-1.62)

1.03×10^-9

1.37 (1.28-1.47)

3.28×10^-18

rs7756992

CDKAL1

C

1.42 (1.32-1.53)

7.98×10^-20

1.41 (1.25-1.58)

9.14×10^-9

1.42 (1.33-1.51)

4.98×10^-27

rs864745

JAZF1

T

1.31 (1.22-1.42)

5.56×10^-12

1.29 (1.14-1.46)

4.19×10^-8

1.31 (1.22-1.40)

1.07×10^-15

rs564398

CDKN2B

A

1.46 (1.34-1.59)

4.37×10^-19

1.38 (1.20-1.59)

9.3×10^-6

1.44 (1.34-1.55)

2.54×10^-23

rs7901695

TCF7L2

C

1.45 (1.34-1.57)

1.44×10^-20

1.34 (1.19-1.52)

1.36×10^-6

1.42 (1.32-1.51)

1.27×10^-24

rs1495377

NR

G

1.25 (1.16-1.35)

1.27×10^-08

1.37 (1.21-1.56)

5.23×10-7

1.29 (1.18-1.41)

1.04×10^-8

rs11634397

ZFAND6

T

1.32 (1.22-1.42)

1.44×10^-12

1.23 (1.10-1.38)

2.17×10^-4

1.29 (1.21-1.37)

2.23×10^-15

rs8042680

PRC1

A

1.47 (1.37-1.58)

8.03×10^-27

1.56 (1.39-1.75)

1.21×10^-13

1.49 (1.41-1.59)

9.82×10^-39

^aMultiple testing was adjusted using Bonferroni correction
^bResults from MESA and ARIC were combined using random-effects meta-analysis