Association of GRS with T2D prevalence at enrollment

Study

OR (95% CI, tertile 3 vs. tertile 1; P-value)

P for trend

   ARIC

1.78 (1.45-2.19; P<0.0001)

<0.0001

   FOS

--

--

   MESA

2.63 (1.97-3.51; P<0.0001)

<0.0001

Pooled

2.15 (1.47-3.14; P<0.0001)

1.5×10^-10

Association of GRS with T2D prevalence at the end of follow-up

Study

OR (95% CI, tertile 3 vs.  tertile 1; P-value)

P for trend

   ARIC

1.64 (1.39-1.92; P<0.0001)

<0.0001

   FOS

2.65 (1.78-3.96; P<0.0001)

<0.0001

   MESA

2.18 (1.71-2.78; P<0.0001)

<0.0001

Pooled

2.08 (1.59-2.74; P<0.0001)

4.9×10^-12

Association of GRS with incident T2D

Study

HR (95% CI, tertile 3 vs. tertile 1; P-value)

P for trend

   ARIC

1.31 (1.08-1.57; P=0.0008)

0.0008

   FOS

2.64 (1.84-3.79; P<0.0001)

<0.0001

   MESA

                           1.32 (0.95-1.83; P=0.10)

0.26

Pooled

                           1.62 (1.08-2.44; P=0.02)

1.5×10^-14

*All ORs and P-values adjusted for age, sex, race, current smoking, BMI, HDL, LDL and SBP