Predicted riska

Predicted risk based on known risk factors + GRS

0-5%

5-10%

10-20%

≥20%

Cases

0-5%

17 (57%)

13 (43%)   

0

0

5-10%

18 (10%)

107 (61%)

50 (29%)

0

10-20%

0

91 (10%)

582 (61%)

276 (29%) 

≥ 20%

0

0

219 (9%)

2269 (91%)

Non-cases

0-5%

557 (84%)

109 (16%)

0

0

5-10%

497 (17%)

1816 (64%)

533 (19%)

10-20%

0

1114 (19%)

3796 (66%)

879 (15%)              

≥ 20%

0

0

932 (20%)

3738 (80%)

Net reclassification improvement of GRS for T2D

Individual reclassified

NRI

P-value

Up

Down

Cases

339

328

0.003

0.67

Non-cases

1518

2543

0.073

<0.0001

Total

-

-

0.076

<0.0001

^a Predicted risk based on known risk factors only, including age, sex, race, current smoking, BMI, HDL, LDL and SBP