Criteria for the diagnosis of DM
Any one of the following:
1. Classic symptoms of DMa + random PG concentrations ≥ 200 mg/dL (11.1 mM)
2. FPG ≥ 126 mg/dL (7.0 mM). Fasting is defined as no caloric intake for ≥ 8 hours
3. 2-hour PG ≥ 200 mg/dL (11.1 mM) during an OGTTb
4. A1Cc ≥ 6.5%
In the absence of unequivocal hyperglycemia accompanied by acute metabolic decompensation,
criteria 2–4 must be confirmed by repeat testing on another day.
Criteria for normal FPG and IFG or IGT
- FPG
WHO criteria
FPG < 110 mg/dL (6.1 mM) = normal fasting glucose
FPG ≥ 110 mg/dL (6.1 mM) and <126 mg/dL (7.0 mM) = IFG
2003 ADA consensus
FPG < 100 mg/dL (5.6 mM) = normal fasting glucose
FPG ≥ 100 mg/dL (5.6 mM) and <126 mg/dL (7.0 mM) = IFG
OR
- OGTT
2-hour PG < 140 mg/dL (7.8 mM) = normal glucose tolerance
2-hour PG ≥ 140 mg/dL (7.8 mM) and < 200 mg/dl (11.1 nM) = IGT
Prediabetic states based on A1C level
2010 ADA consensus: 5.7%–6.4%
International expert committee: 6.0%–6.4% |
Notes: a: Classic symptoms of DM include polyuria, polydipsia, and unexplained
weight loss; bOGTT: the test should be performed as described by WHO, using
a glucose load containing equivalent of 75 g anhydrous glucose dissolved in
water; cA1C should be performed using a method certified by the National
Glycohemoglobin Standardization Program (NGSP) and standardized to the
Diabetes Control and Complications Trial (DCCT) reference assay.
Abbreviations: (WHO) World Health Organization; (ADA) American Diabetes
Association; (DM) Diabetes Mellitus; (PG) Plasma Glucose; (FPG) Fasting Plasma
Glucose; (IFG) Impaired Fasting Glucose; (IGT) Impaired Glucose Tolerance;
(OGTT) OGTTtest. |
